痤疮患者外周血IL-6、TNF-α表达水平及其与痤疮严重程度的相关性研究  

Study of the correlation between the expression levels of IL-6 and TNF-α,and the severity of acne in acne patients

作　　者：莫惠芳[1] 钟敏华 储开宇[1] 罗文峰[1] 钟卫红[1] 汤勇军[1] 陈怡君 陈海生[2] MO Huifang;ZHONG Minhua;CHU Kaiyu;LUO Wenfeng;ZHONG Weihong;TANG Yongjun;CHEN Yijun;CHEN Haisheng(Department of Dermatology,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China;Department of Clinical Laboratory,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China)

机构地区：[1]佛山市中医院皮肤科,广东佛山528000 [2]佛山市中医院检验科,广东佛山528000

出　　处：《皮肤性病诊疗学杂志》2021年第3期186-189,共4页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：佛山市科技攻关项目(2018AB000951)。

摘　　要：目的:检测痤疮患者外周血中IL-6、TNF-α表达水平,并分析两者与痤疮严重程度的相关性。方法:收集我院皮肤科门诊诊治的寻常痤疮患者114例,其中轻度35例、中度43例、重度36例,另选择同时期健康体检者30例作为对照组。使用化学发光法检测治疗前及治疗后4周血清中IL-6、TNF-α的水平,并对结果进行比较分析。结果:轻、中、重度痤疮患者外周血中IL-6水平差异有统计学意义(P<0.01),而TNF-α水平无明显差异(P=0.243)。轻度、中度、重度患者IL-6水平均高于对照组(P值均<0.05),而不同严重程度患者组间IL-6水平差异无统计学意义(P值均>0.05)。痤疮严重程度与IL-6、TNF-α水平均无明显相关性(P值均>0.05)。结论:IL-6参与了痤疮的炎症反应,但不能用于评估痤疮病情的严重程度。TNF-α与痤疮之间的关系仍需进一步深入研究。Objective:To assess the correlation of IL-6 and TNF-αlevels and the severity of acne.Methods:Blood samples were collected from 30 normal controls and 114 patients with acne vulgaris before and after 4-week treatments.According to the severity of acne,patients were divided into mild,moderate and severe groups.Chemilunescence was used to measure expression levels of IL-6 and TNF-α.Rusults:The expression levels of IL-6,but not TNF-α,in patients with acne were significantly higher than that in the controls(for IL-6,P<0.01;for TNF-α,P=0.243).However,there were no differences in IL-6 levels among three acne groups(all P>0.05).Expression levels of IL-6 and TNF-αwere not correlated with the severity of acne(both P>0.05).Conclusions:IL-6 is involved in the inflammatory response in acne,but cannot serve as an indicator of disease severity.Further study is needed to determine the relationship between TNF-αand acne.

关 键 词：痤疮 白介素-6 肿瘤坏死因子-Α 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]