Self-made allostery: endogenous COMP antagonizes pathologic AT1_(A)R signaling  

作　　者：Ama Dedo Okyere Douglas G.Tilley 

机构地区：[1]Center for Translational Medicine,Lewis Katz School of Medicine,Temple University,Philadelphia,PA,19140,USA

出　　处：《Cell Research》2021年第7期730-731,共2页细胞研究（英文版）

摘　　要：The identification and development of biased modulators of proximal G protein-coupled receptor(GPCR)signaling to prevent pathological disease progression has been at the forefront of recent drug discovery efforts.Recently,Fu et al.identified cartilage oligomeric matrix protein(COMP)as an endogenous negative allosteric modulator ofβ-arrestin(βarr)-dependent angiotensin Ⅱ(Ang Ⅱ)Type 1A receptor(AT1 A R)signaling,which attenuates the development of abdominal aortic aneurysm(AAA),a chronic inflammatory vascular disease lacking pharmacological treatment options.

关 键 词：ENDOGENOUS AT1 COMP 

分 类 号：Q2[生物学—细胞生物学]