cGAS-STING信号通路及其触发因素与治疗药物  

Trigger factors and therapeutic drugs of cGAS-STING signaling pathway

作　　者：彭越 周末 金政[3,4] 赵凯 PENG Yue;ZHOU Mo;JIN Zheng;ZHAO Kai(Heilongjiang University Key Laboratory of Microbiology,College of Life Sciences,Heilongjiang University,Harbin 150080,China;Engineering Research Center of Agricultural Microbiology Technology,Ministry of Education,Harbin 150500,China;College of Chemistry,Chemical Engineering and Materials,Heilongjiang University,Harbin 150080,China;Heilongjiang Kaizhenglihua Biological and Chemical Technology Co.,Ltd,Harbin 150080,China)

机构地区：[1]黑龙江大学生命科学学院微生物黑龙江省高校重点实验室,哈尔滨150080 [2]农业微生物技术教育部工程研究中心,哈尔滨150500 [3]黑龙江大学化学化工与材料学院,哈尔滨150080 [4]黑龙江凯正利华生物化工科技有限公司,哈尔滨150080

出　　处：《生命的化学》2021年第5期938-945,共8页Chemistry of Life

基　　金：国家重点研发计划(2017YFD0500603);国家自然科学基金项目(31771000);黑龙江省杰出青年科学基金项目(JC2018008);黑龙江省高校基本科研业务费黑龙江大学专项资金项目(RCCXYJ201906);哈尔滨市“雏鹰计划”暨科技企业培育专项(2020CYJBCG0306)。

摘　　要：环状鸟苷单磷酸-腺苷单磷酸合酶(cyclic GMP-AMP synthase, cGAS)是一种能够与dsDNA结合的胞质核酸传感器。在无dsDNA情况下,cGAS保持抑制状态;在cGAS激活时,衔接蛋白干扰素基因刺激蛋白(stimulator of interferon genes, STING)被激活,触发级联反应,产生促炎细胞因子和Ⅰ型干扰素(typeⅠinterferon,Ⅰ-IFN)。cGAS-STING信号通路能够增强机体对感染的抵抗力,但是cGASSTING信号通路的过度激活可能会导致严重的炎症反应,影响自身免疫甚至产生疾病。本文系统回顾了cGAS-STING信号通路及其触发因素,并探讨了其与自身免疫性疾病的联系和药物治疗的进展。Cyclic GMP-AMP synthase(cGAS) is a cytoplasmic nucleic acid sensor which can bind to dsDNA. cGAS remained inhibitory in the absence of dsDNA. But when cGAS is activated, stimulator of interferon gene(STING) is activated, triggering cascade reaction, producing proinflammatory cytokines and type Ⅰ interferon(Ⅰ-IFN). The cGAS-STING signaling pathway can enhance the body’s resistance to infection, but the excessive activation of cGAS-STING signaling pathway may lead to serious inflammation, affect autoimmune and produce diseases. This paper systematically reviewed the cGAS-STING signaling pathway and trigger factors, as well as its association with autoimmune diseases and drug treatment progress.

关 键 词：cGAS-STING信号通路 触发因素 自身免疫性疾病 药物治疗 

分 类 号：R593.2[医药卫生—内科学]