血清非磷酸化未羧化基质Gla蛋白与绝经后骨质疏松症的关系  

Relationship between serum desphospho-uncarboxylated matrix Gla protein and postmenopausal osteoporosis

作　　者：方向南[1] 王瑒[1] 郭莉[1] 洪世华[1] 谢满[2] 吕维名[1] 胡承[3] Fang Xiangnan;Wang Yang;Guo Li;Hong Shihua;Xie Man;Lyu Weiming;Hu Cheng(Department of Endocrinology,The First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China;Department of Health Management Center,The First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China;Shanghai Diabetes Institute,Shanghai Sixth′s People Hospital,Shanghai Jiao Tong University,Shanghai 200000,China)

机构地区：[1]赣南医学院第一附属医院内分泌科,赣州341000 [2]赣南医学院第一附属医院健康体检中心,赣州341000 [3]上海交通大学附属第六人民医院上海市糖尿病研究所,200000

出　　处：《国际内分泌代谢杂志》2021年第3期164-167,190,共5页International Journal of Endocrinology and Metabolism

基　　金：赣州市科技局计划(GZ2019ZSF054)。

摘　　要：目的探讨血清非磷酸化未羧化基质Gla蛋白(dp-ucMGP)与绝经后骨质疏松症(PMOP)及骨代谢指标的关系。方法选取2017年12月至2019年12月在赣南医学院第一附属医院健康体检中心就诊或内分泌代谢科住院的绝经后女性共248名作为研究对象。采用双能X线吸收骨密度仪(DXA)测定骨密度(BMD)。根据BMD将研究对象分为骨量正常组(n=86)、骨量减少组(n=64)和PMOP组(n=98)。采用酶联免疫吸附法(ELISA)检测血清dp-ucMGP水平。并检测血钙、血磷、血β胶原降解产物Ⅰ型胶原羧基端肽(β-CTX)和Ⅰ型前胶原N-端前肽(PINP)等骨代谢指标。结果3组间年龄、绝经年限、体重指数(BMI)、骨钙素、β-CTX、PINP和dp-ucMGP差异有统计学意义(P<0.05)。Pearson相关分析表明血清dp-ucMGP与年龄(r=0.254,P=0.042)、绝经年限(r=0.343,P=0.036)、β-CTX(r=0.023,P=0.025)呈正相关,与BMI(r=-0.169,P=0.041)、腰椎BMD(r=-0.176,P=0.031)、股骨颈BMD(r=-0.234,P=0.025)和骨钙素(r=-0.176,P=0.034)呈负相关。二元logistic回归分析提示年龄(OR=1.164,P=0.024)、绝经年限(OR=1.151,P=0.031)、β-CTX(OR=1.122,P=0.037)和dp-ucMGP(OR=1.244,P=0.033)为PMOP的危险因素,校正年龄和绝经年限后,dp-ucMGP(OR=1.237,P=0.045)仍为PMOP的危险因素。结论血清dp-ucMGP可能成为PMOP的潜在生物标志物。Objective To investigate the relationship between serum desphospho-uncarboxylated matrix Gla protein(dp-ucMGP)and bone metabolic biomarkers in postmenopausal osteoporosis(PMOP)patients.Methods A total of 248 postmenopausal women who attended the Department of Health Management Center,or the Department of Endocrinology and Metabolism in the First Affiliated Hospital of Gannan Medical College from December 2017 to December 2019 were enrolled.Bone mineral density(BMD)was measured by dual-energy X-ray absorptiometry(DXA).Based on BMD,the participants were divided into normal bone mass group(n=86),osteopenia group(n=64)and PMOP group(n=98).Serum dp-ucMGP was measured by enzyme-linked immunosorbent assay(ELISA).Bone metabolic biomarkers such as calcium,phosphorus,β-crosslinking C-telopeptide of typeⅠcollagen(β-CTX)and procollagen typeⅠN-terminal propeptide(PINP)were also measured.Results The differences of age,years since menopause,BMI,osteocalcin,β-CTX,PINP,and dp-ucMGP among three groups were significant(P<0.05).Pearson correlation analysis indicated that serum dp-ucMGP was positively correlated with age(r=0.254,P=0.042),years since menopause(r=0.343,P=0.036)andβ-CTX(r=0.023,P=0.025),and negatively correlated with BMI(r=-0.169,P=0.041),lumbar spine BMD(r=-0.176,P=0.031),femoral neck BMD(r=-0.234,P=0.025)and osteocalcin(r=-0.176,P=0.034).Binary logistic regression analysis suggested that age(OR=1.164,P=0.024),years since menopause(OR=1.151,P=0.031),β-CTX(OR=1.122,P=0.037)and dp-ucMGP(OR=1.244,P=0.033)were risk factors for PMOP.After adjusted for age and years since menopause,dp-ucMGP(OR=1.237,P=0.045)was also an risk factor for PMOP.Conclusion Serum dp-ucMGP may be a potential biomarker of PMOP.

关 键 词：非磷酸化未羧化基质Gla蛋白 绝经后骨质疏松症 骨密度 骨代谢指标 

分 类 号：R580[医药卫生—内分泌]