MEBT/MEBO联合异种(猪)脱细胞真皮基质敷料在深Ⅱ度烧伤中的应用效果分析  

Analysis of the Application Effect of MEBT/MEBO Combined with Xenogeneic(Porcine)Acellular Dermal Matrix Dressing in Deep Second Degree Burns

作　　者：文正荣 王亚明 王路东 刘莹 康义华 Wen Zhengrong;Wang Yaming;Wang Ludong;Liu Ying;Kang Yihua(Chuxiong Prefecture Hospital Affiliated with Chuxiong Medical College/General Surgery Department 2,The People’s Hospital of Chuxiong Yi Autonomous Prefecture,Chuxiong Prefecture,Yunan 675000,China)

机构地区：[1]楚雄医药高等专科学校附属楚雄州医院/楚雄彝族自治州人民医院普外二科,云南楚雄675000

出　　处：《中国烧伤创疡杂志》2021年第4期251-255,共5页The Chinese Journal of Burns Wounds & Surface Ulcers

基　　金：2019年楚雄医药高等专科学校科研项目(2019YYXM02)。

摘　　要：目的对比分析烧伤创疡再生医疗技术(MEBT/MEBO)联合异种(猪)脱细胞真皮基质敷料治疗深Ⅱ度烧伤创面的临床效果。方法选取2014年12月至2018年12月楚雄彝族自治州人民医院收治的分别采用MEBT/MEBO联合异种(猪)脱细胞真皮基质敷料治疗的25例深Ⅱ度烧伤患者(设为观察1组)以及采用磺胺嘧啶银乳膏联合凡士林油纱治疗的25例深Ⅱ度烧伤患者(设为观察2组)作为研究对象,对比观察两组患者创面愈合时间、疼痛程度及创面感染情况。结果观察1组患者创面愈合时间为(14.48±0.87)d,明显短于观察2组患者的创面愈合时间(18.12±0.73)d(t=16.025,P<0.001)。治疗第1、4、7、10天,观察1组患者创面疼痛程度均明显轻于观察2组(t=12.314、2.587、4.957、3.145,P=0.000、0.013、0.000、0.003);治疗第4、7天,观察1组患者创面分泌物细菌培养阳性例数明显少于观察2组(χ^(2)=5.333、5.711,P=0.021、0.017)。结论MEBT/MEBO联合异种(猪)脱细胞真皮基质敷料可明显减轻深Ⅱ度烧伤患者创面疼痛程度,抑制创面感染,缩短创面愈合时间,疗效显著。Objective To compare and analyze the clinical effect of the regenerative medical technology for burns,wounds and ulcers(MEBT/MEBO)combined with xenogeneic(porcine)acellular dermal matrix dressings in the treatment of deep second degree burns.Methods Fifty patients with deep second degree burns,admitted to The People’s Hospital of Chuxiong Yi Autonomous Prefecture from December 2014 to December 2018,were selected as research subjects,of which 25 patients received the treatment of MEBT/MEBO combined with xenogeneic(porcine)acellular dermal matrix dressings(set as observation group 1),and the other 25 patients were treated with Sulfadiazine Silver Cream combined with Vaseline gauze(set as observation group 2).The wound healing time,pain degree and wound infection condition of patients were compared between the two groups.Results The wound healing time in the observation group 1 was(14.48±0.87)d,which was significantly shorter than(18.12±0.73)d in the observation group 2(t=16.025,P<0.001).On day 1,4,7,and 10 of treatment respectively,the wound pain degrees in the observation group 1 were all significantly lower than that in the observation group 2(t=12.314,2.587,4.957 and 3.145,P=0.000,0.013,0.000 and 0.003).On day 4 and 7 of treatment,the number of patients with positive bacterial culture results of wound secretions in the observation group 1 was significantly less than that in the observation group 2(χ^(2)=5.333 and 5.711,P=0.021 and 0.017).Conclusion MEBT/MEBO combined with xenogeneic(porcine)acellular dermal matrix dressing can significantly reduce the pain degree of wounds in patients with deep second degree burns,inhibit wound infection and shorten wound healing time,achieving good curative effect.

关 键 词：烧伤创疡再生医疗技术 异种(猪)脱细胞真皮基质 磺胺嘧啶银 烧伤 深Ⅱ度 

分 类 号：R644[医药卫生—外科学]