丁酸梭菌介导TLRs/NLRs信号通路调控仔猪肠道损伤分子机制的研究进展  

Advances in the molecular mechanism of Clostridium butyrate mediated TLRs/NLRs signaling pathway regulating intestinal injury in piglets

作　　者：李玉鹏[1] 李海花 尚智援 窦彩霞 梁世岳 席燕燕 乔家运 LI Yupeng;LI Haihua;SHANG Zhiyuan;DOU Caixia;LIANG Shiyue;XI Yanyan;QIAO Jiayun(Institute of Animal Husbandry and Veterinary Science,Tianjin Academy of Agricultural Sciences,Xiqing District,Tianjin 300381,China;College of animal science and animal medicine,Tianjin Agricultural University,Xiqing District,Tianjin 300384,China;Tianjin Normal University,Xiqing District,Tianjin 300387,China;Institute of Animal Husbandry and Veterinary Medicine,Henan Academy of Agricultural Sciences,Zhengzhou,Henan Province 450002,China)

机构地区：[1]天津市农业科学院畜牧兽医研究所,天津西青300381 [2]天津农学院动物科学与动物医学学院,天津西青300384 [3]天津师范大学生命科学学院,天津西青300387 [4]河南省农业科学院畜牧兽医研究所,河南郑州450002

出　　处：《中国饲料》2021年第15期1-5,共5页China Feed

基　　金：天津市农业科学院青年科研人员创新研究与实验项目(2020005);天津市武清区科技计划项目(WQKW202012);天津市“131”创新型人才团队(20180338)。

摘　　要：近年来,丁酸梭菌作为一种良好、安全的添加剂,正在被越来越多地应用到畜牧业中。尽管已在丁酸梭菌的特征、营养作用及畜禽饲粮中的应用效果等方面开展过较深入的研究,但是对于丁酸梭菌调节肠道黏膜免疫通路方面的研究尚不系统,对丁酸梭菌调节致病菌感染仔猪肠道损伤的分子机制也未完全认识。因此,本研究对丁酸梭菌介导TLRs/NLRs信号通路调控仔猪肠道损伤的分子机制进行了综述。In recent years,as a good and safe additive,Clostridium butyrate is being used in animal husbandry increasingly.Although the previous have been carried out the studies in the characteristics,nutritional function and the effect application on livestock and poultry diet of Clostridium butyrate.However,studies on the regulation of intestinal mucosal immune pathways by Clostridium butyrate have not been systematic,and the molecular mechanism of Clostridium butyrate regulating intestinal injury of piglets which infected by pathogenic bacterium has not been fully understood.Therefore,this study summarized the molecular mechanism of Clostridium butyrate mediated TLRs/NLRs signaling pathway regulating intestinal injury of piglets.

关 键 词：丁酸梭菌 仔猪 信号通路 肠道损伤 

分 类 号：S816.7[农业科学—饲料科学]