Two new ar-bisabol sesquiterpenes from the stem bark of Fraxinus sielboldiana  

作　　者：Sheng Lin Yan-ling Zhang Ming-tao Liu Jia-chen Zi Mao-luo Gan Wei-xia Song Xiao-na Fan Su-juan Wang Yong-chun Yang Jian-gong Shi 

机构地区：[1]State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,and Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,People’s Republic of China

出　　处：《Acta Pharmaceutica Sinica B》2011年第2期89-92,共4页药学学报（英文版）

基　　金：Financial support from the National Natural Sciences Foundation of China(NNSFC,Grant nos.30825044 and 20932007);the National Science and Technology Project of China(Nos.2009ZX09311-004 and 2009ZX09301-003-4-1)is acknowledged.

摘　　要：Two new ar-bisabol sequiterpenes,(+)-(7S,10S)-10-epi-7,10-epoxy-3-hydroxy-ar-bisabol-11-ol(1)and(+)-(7R,8R,10S)-10-epi-7,10-epoxy-8-hydroxy-ar-bisabol-11-ol(2),have been isolated by a combination of various column chromatographic techniques including reversed-phase semipreparative HPLC from an ethanol extract of the stem bark of Fraxinus sielboldiana.Their structures were determined by spectroscopic methods including IR,MS,and 1D and 2D NMR experiments.This is the first report of sequiterpenes in the genus Fraxinus.

关 键 词：Fraxinus sielboldiana Blume Ar-bisabol sequiterpenes (+)-(7S 10S)-10-epi-7 10-epoxy-3-hydroxyar-bisabol-11-ol (+)-(7R 8R 10S)-10-epi-7 10-epoxy-8-hydroxyar-bisabol-11-ol 

分 类 号：R28[医药卫生—中药学]