妇女尿微生物组与尿失禁、下尿路疾病之间的关系研究进展  

Correlation among female urine microbiome,urinary incontinence and lower urinary tract diseases

作　　者：彭彪 李天杰 周杭 田道明 柯坤彬[1] 李松[1] 申吉泓[1] PENG Biao;LI Tianjie;ZHOU Hang;TIAN Daoming;KE Kunbin;LI Song;SHEN Jihong(Department of Urology,The First Affiliated Hospital of Kunming Medical University,Training Base for Female Pelvic Floor Diseases of Yunnan Province,Chinese Medical Association,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院泌尿外科,中华医学会云南省女性盆底疾病培训基地,云南昆明650032

出　　处：《现代泌尿外科杂志》2021年第7期618-622,共5页Journal of Modern Urology

基　　金：云南省教育厅基金资助项目(No.2020J0167)。

摘　　要：尿失禁(UI)和下尿路疾病是一大类严重的泌尿妇科疾病,尤其在中老年妇女中患病率很高。最新的研究表明尿微生物群与UI及相关下尿路疾病(尿路感染、膀胱过度活动症、间质性膀胱炎/膀胱疼痛综合征)相关联,患有尿失禁及相关下尿路疾病的患者与无症状个体相比较,尿微生物组存在差异。调控尿微生物组还可对急迫性尿失禁及膀胱过度活动症的治疗产生影响,因此通过生物疗法(针对尿道的益生菌、噬菌体制剂及进行尿微生物菌群移植)恢复尿道健康被提上了研究日程。Urinary incontinence(UI)and lower urinary tract diseases are prevalent among middle-aged and elderly women.Latest research shows that urinary microbiota is associated with UI and lower urinary tract diseases,including urinary tract infection,overactive bladder,interstitial cystitis/bladder painful syndrome,and so on.There are significant differences in urinary microbiome between symptomatic and asymptomatic individuals.Regulation of the urinary microbiome can also have an impact on the treatment of urge incontinence and overactive bladder.Therefore,the restoration of urinary tract health through biological therapies,such as urethral probiotics,phage preparations and transplantation of urinary microbiota,is put on the research agenda.

关 键 词：尿微生物组 尿微生物群 尿失禁 下尿路疾病 

分 类 号：R694.54[医药卫生—泌尿科学]