核桃青皮活性成分胡桃醌抗肿瘤作用研究进展  

Research Progress on Anti-tumor Effect of Juglonethe Active Component of Walnut Green Husks

作　　者：孙卉 何志贵 师俊玲 SUN Hui;HE Zhigui;SHI Junling(College of Recreation and Health,Guilin Tourism University,Guilin,Guangxi 541006,China;College of Life Science,Northwestern Polytechnical University,Xi'an,Shaanxi 710072,China)

机构地区：[1]桂林旅游学院休闲与健康学院,广西桂林541006 [2]西北工业大学生命学院,陕西西安710072

出　　处：《农产品加工》2021年第14期86-90,共5页Farm Products Processing

基　　金：国家重点研发计划(2017YFE0105300);国家级大学生创新创业训练计划项目(202011837007);广西高校中青年教师科研基础能力提升项目(2021KY0830);桂林旅游学院教育教学研究改革项目(2020XJJG019)。

摘　　要：胡桃醌是核桃青皮中主要抗肿瘤活性成分之一,体内体外研究表明其对胰腺癌、乳腺癌、前列腺癌、宫颈癌等多种癌细胞具有较高的抑制活性。对从核桃青皮中分离到的胡桃醌及其衍生物进行梳理,阐述了胡桃醌抗肿瘤作用机制,以期为胡桃醌的深入研究和抗癌新药的研发提供参考。Juglone is one of the main anti-tumor active components of walnut green husks.Studies in vitro and in vivo have shown that it has significantly inhibitory activities on pancreatic cancer cells,breast cancer cells,prostate cancer cells,cervical cancer cells and other cancer cells.In this paper,juglone and its derivatives isolated from walnut green husks were reviewed,and the mechanism of anti-tumor effect of juglone was expounded,so as to provide reference for further research on juglone and research and development of new anticancer drugs.

关 键 词：核桃青皮 胡桃醌 抗肿瘤作用 研究进展 

分 类 号：O629[理学—有机化学]