One-Pot Synthesis of Polysubstituted Pyrroles via Sequential Ketenimine Formation/Ag(l)-Catalyzed Alkyne Cycloisomerisation Starting from Ylide Adducts  

作　　者：Jun Xiong Zhi-Ying Mu Gang Yao Jia-An Zhang Qi-Xun Feng Hui-Ting He Yong-Long Pang Hang Shi Ming-Wu Ding 

机构地区：[1]School of Pharmacy,Hubei University of Science and Technology,Xianning,Hubei 437100,China [2]Key Laboratory of Pesticide&Chemical Biology of Ministry of Education,Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis,Central China Normal University,Wuhan,Hubei 430079,China

出　　处：《Chinese Journal of Chemistry》2021年第6期1553-1557,共5页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(No.21572075);the 111 Project B17019;the Research Project of Hubei Provincial Department of Education(No.Q20192806);the Doctoral Research Fund of Hubei University of Science and Technology(No.BK201808).

摘　　要：A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(l)-catalyzed alkyne cycloisomerisation has been developed.The easily accessible phosphorane ylide derivatives reacted with isocyanates,producing highly active ketenimines that were then treated with amines,which afforded substituted pyrroles by a S-exo-dig cyclization/isomerization in the presence of a Ag(l)catalyst in good overall yields.

关 键 词：Pyrrole Ag⑴-catalysed KETENIMINE YLIDE ONE-POT 

分 类 号：O62[理学—有机化学]