Reductive Coupling of Aryl Halides via C-H Activation of Indene  

作　　者：Bo-Sheng Zhang Ying-Hui Yang Fan Wang Xue-Ya Gou Xi-Cun Wang Yong-Min Liang Yuke Li Zheng-Jun Quan 

机构地区：[1]College of Chemistry and Chemical Engineering,Gonsu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials,Northwest Normal University,Lanzhou,Gansu 730070,China [2]State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu 730000,China [3]Department of Chemistry and Centre for Scientific Modeling and Computation,Chinese University of Hong Kong,Shatin,Hong Kong,China

出　　处：《Chinese Journal of Chemistry》2021年第6期1573-1579,共7页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.NSF22061038,NSF22067018);the Long Yuan Youth Innovative Project of Gansu Province(No.2019-39);the Northwest Normal University Young Scholars Research Capacity Improvement Program(No.NWNU-LKQN-2020-04);Computations reported in this paper were performed on the computer clusters at the Centre for Scientific Modeling and Computation,CUHK.

摘　　要：This paper describes the first case of a reductive coupling reaction with indene,a non-heteroatom olefin used as a reducing agent.The scope of the substrate is wide.The homo-coupling,cross-coupling,and synthesis of 12 and 14-membered rings were realized.The control experiment,indene-product curve and density functional theory calculations showed that the η^(3)-palladium indene intermediate was formed by C-H activation in the presence of cesium carbonate.We speculate that the final product was obtained through a Pd(IV)intermediate or aryl ligand exchange.In addition,we excluded the formation of palladium anion(Pd(0)^(-))intermediates.

关 键 词：C-C coupling PALLADIUM REDUCTION INDENE C-H activation 

分 类 号：O62[理学—有机化学]