高糖损伤背根神经节细胞的研究  

Research of high glucose on the injury of dorsal root ganglion cells

作　　者：刘亚东[1] 卫中庆[2] 张思聪[2] 卢晓明[1] Liu Yadong;Wei Zhongqing;Zhang Sicong;Lu Xiaoming(Department of Urology,the Third People′s Hospital of Yancheng,Yancheng 224000,China;Department of Urology,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]盐城市第三人民医院泌尿外科,224000 [2]南京医科大学第二附属医院泌尿外科,210000

出　　处：《国际外科学杂志》2021年第6期410-416,共7页International Journal of Surgery

基　　金：国家自然科学基金(8187030928);盐城市医学科技发展计划项目(YK2020075)。

摘　　要：糖尿病膀胱功能障碍是常见的泌尿系统糖尿病并发症之一。目前认为,糖代谢的紊乱、局部组织缺血、超氧化物诱导的自由基产生以及轴突转运障碍等多病因共同参与糖尿病膀胱神经功能障碍的发生、发展。氧化应激被认为是上述病因的核心机制,它可能通过干扰细胞内氧化与抗氧化平衡、神经营养因子代谢及细胞信号转导通路等,影响细胞核内转录及翻译过程,导致细胞内多条重要细胞通路功能障碍及细胞膜稳定性下降,最终可能导致神经细胞凋亡。因此,纠正血糖,改善背根神经节细胞周围的微环境,保护线粒体膜的稳定性或许是治疗糖尿病膀胱神经功能障碍的潜在方法。Diabetic bladder dysfunction is one of the most common complications of urinary tract in diabetes.It is believed that the disorders of glucose metabolism,local tissue ischemia,superoxide-induced free radical production and axonal transport disorder are all involved in the development of diabetic bladder nerve dysfunction.Oxidative stress is believed to be the core mechanism of the above mentioned etiology.It may affect the transcription and translation process in the nucleus by interfering with the balance of intracellular oxidation and antioxidant,metabolism of neurotrophic factors and cellular signal transduction pathways,resulting in dysfunction of several important cellular pathways and decreased membrane stability.And eventually lead to nerve cell apoptosis.Therefore,controlling blood glucose,improving the microenvironment around dorsal root neurons,and protecting the stability of mitochondrial membrane may be potential methods for the treatment of diabetic bladder nerve dysfunction.

关 键 词：高糖 糖尿病性膀胱 背根神经节细胞 线粒体 糖尿病并发症 

分 类 号：R587.2[医药卫生—内分泌] R694[医药卫生—内科学]