药物涂层球囊治疗对冠状动脉再狭窄老年患者靶血管内膜反应、靶病变血运重建的影响  

Effect of drug-coated balloon on intimal response of the target blood vessels and revascularization of target lesions in elderly patients with coronary artery restenosis

作　　者：高炬 付晓辉 陶贵周 屈宝泽 Ju Gao;Xiao-hui Fu;Gui-zhou Tao;Bao-ze Qu(Department of Cardiology,The First Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning 121001,China)

机构地区：[1]锦州医科大学附属第一医院心内科,辽宁锦州121001

出　　处：《中国现代医学杂志》2021年第14期79-84,共6页China Journal of Modern Medicine

摘　　要：目的探讨药物涂层球囊治疗冠状动脉再狭窄老年患者对靶血管内膜反应、靶病变血运重建的影响及安全性。方法选取2017年11月—2019年1月锦州医科大学附属第一医院收治的冠状动脉再狭窄老年患者198例,根据随机数字表法分为研究组与对照组,每组99例。对照组采取切割球囊治疗,研究组采取药物涂层球囊治疗。对两组治疗前和治疗3个月、6个月后靶血管内膜反应、心功能、中国心血管病人生活质量评定问卷(CCQQ)评分、不良心血管事件发生率、管腔再狭窄率及靶病变血运重建发生率进行比较。结果两组最小腔径、最小管腔面积比较,差异有统计学意义(P<0.05),两组左室射血分数、NT-proBNP及每搏输出量比较,差异有统计学意义(P<0.05),两组不良心血管事件总发生率比较,差异无统计学意义(P>0.05),对照组靶病变血运重建发生率高于研究组(P<0.05)。两组CCQQ评分比较,差异有统计学意义(P<0.05)。结论药物涂层球囊治疗冠状动脉再狭窄老年患者可明显改善靶血管内膜反应,降低靶病变血运重建发生率,促进心功能恢复,可以改善生活质量。Objective To investigate the safety of drug-coated balloon(DCB)in the treatment of coronary artery restenosis in elderly patients and its effects on the intimal response of target vessels and the revascularization of target lesions(TLR).Methods A total of 198 elderly patients with coronary artery restenosis in our hospital from November 2017 to January 2019 were enrolled and randomly divided into study group and control group,with 99 cases in each group.The control group was treated with the cutting balloon and the study group was treated with DCB.The intimal response of the target blood vessels[minimum lumen diameter of main branch(MLD)and minimum lumen area(MLA)],cardiac function[left ventricular ejection fraction(LVEF),N-terminal pro-brain natriuretic peptide(NT-proBNP)and stroke volume(SV)],Chinese questionnaire of quality of life in patients with cardiovascular diseases(CCQQ)score,the incidence of adverse cardiovascular events,and the rates of restenosis and TLR were measured before the treatment and 3 and 6 months after the treatment in two groups.Results MLD and MLA were different between the study group and the control group(P<0.05),and LVEF,NT-proBNP,and SV were also different between the two groups(P<0.05).There was no significant difference in the incidence of adverse cardiovascular events between the study group and the control group(P>0.05).Besides,the incidence of TLR and CCQQ scores differed between the two groups(P<0.05).Conclusions DCB treatment can significantly improve the intimal response of the target blood vessels,reduce the incidence of TLR,promote cardiac function recovery,and enhance quality of life in elderly patients with coronary artery restenosis.

关 键 词：冠状动脉再狭窄 药物涂层球囊/组织扩张装置 内膜反应/血管内膜 血运重建/心肌血管重建术 心房功能 心室功能 老年人 

分 类 号：R541.4[医药卫生—心血管疾病]