High Performance In Vivo Near-IR (>1 μm) Imaging and Photothermal Cancer Therapy with Carbon Nanotubes  

作　　者：Joshua T.Robinson Kevin Welsher Scott M.Tabakman Sarah P.Sherlock Hailiang Wang Richard Luong Hongjie Dai 

机构地区：[1]Department of Chemistry,Stanford University,Stanford,CA 94305,USA [2]Department of Comparative Medicine,Stanford University School of Medicine,Stanford,CA 94305,USA

出　　处：《Nano Research》2010年第11期779-793,共15页纳米研究（英文版）

基　　金：This work was supported by Ensysce Biosciences,CCNE-TR at Stanford University and NIH-NCI RO1 CA135109-02.

摘　　要：Short single-walled carbon nanotubes(SWNTs)functionalized by PEGylated phospholipids are biologically non-toxic and long-circulating nanomaterials with intrinsic near infrared photoluminescence(NIR PL),characteristic Raman spectra,and strong optical absorbance in the near infrared(NIR).This work demonstrates the first dual application of intravenously injected SWNTs as photoluminescent agents for in vivo tumor imaging in the 1.0-1.4μm emission region and as NIR absorbers and heaters at 808 nm for photothermal tumor elimination at the lowest injected dose(70μg of SWNT/mouse,equivalent to 3.6 mg/kg)and laser irradiation power(0.6 W/cm2)reported to date.Ex vivo resonance Raman imaging revealed the SWNT distribution within tumors at a high spatial resolution.Complete tumor elimination was achieved for large numbers of photothermally treated mice without any toxic side effects after more than six months post-treatment.Further,side-by-side experiments were carried out to compare the performance of SWNTs and gold nanorods(AuNRs)at an injected dose of 700μg of AuNR/mouse(equivalent to 35 mg/kg)in NIR photothermal ablation of tumors in vivo.Highly effective tumor elimination with SWNTs was achieved at 10 times lower injected doses and lower irradiation powers than for AuNRs.These results suggest there are significant benefits of utilizing the intrinsic properties of biocompatible SWNTs for combined cancer imaging and therapy.

关 键 词：PHOTOTHERMAL cancer SWNT IMAGING treatment 

分 类 号：TB3[一般工业技术—材料科学与工程]