Pharmacokinetic performance of the nitrendipine intravenous submicron emulsion in rats  

作　　者：Jibin Guan Nana Zhao Yinglei Zhai Chunxia Chu Hongming Chen Tianhong Zhang 

机构地区：[1]Shenyang Pharmaceutical University,School of Pharmacy,No.103,Wenhua Road,Shenyang 110016,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2014年第6期330-335,共6页亚洲药物制剂科学（英文）

摘　　要：To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in rats.The plasma concentrations were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry detection(UPLC-MS/MS)through a new validated method.The pharmacokinetic parameters of the nitrendipine submicron emulsion and nitrendipine solution were as follows:AUC_(0-t) 900.76±186.59 versus 687.08±66.24 ng h/ml,C_(max) 854.54±159.48 versus 610.59±235.99 ng/ml,t_(1/2)2.37±1.99 versus 2.80±2.69 h.The relative bioavailability of nitrendipine submicron emulsion to nitrendipine solution was 131.4±11.3%.The developed methods could meet the requirements of bioanalysis.Compared to the solution injection,intravenous submicron emulsion presents higher systematic exposure which can help to improve the therapeutic efficacy.

关 键 词：NITRENDIPINE Submicron emulsion BIOAVAILABILITY Method validation 

分 类 号：TB3[一般工业技术—材料科学与工程]