Studies on the spray dried lactose as carrier for dry powder inhalation  

作　　者：Linna Wu Xu Miao Ziyun Shan Ying Huang Lu Li Xin Pan Qinghe Yao Ge Li Chuanbin Wu 

机构地区：[1]School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China [2]GuangDong Research Center for Drug Delivery Systems,Sun Yat-sen University,Guangzhou 510006,China [3]School of Engineering,Sun Yat-sen University,Guangzhou 510006,China [4]Guangzhou Neworld Pharm.Co.Ltd.,Guangzhou 510006,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2014年第6期336-341,共6页亚洲药物制剂科学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(No.:81173002);the National Science and Technology Support Program(No.:2012BAI35B02).

摘　　要：The purpose of this study was to investigate the spray dried lactose as carrier for dry powder inhalation(DPI).The lactose particles were prepared by spray drying,then the particle size,shape and crystal form were characterized by laser diffraction,scanning electron microscopy(SEM),X-ray diffraction(XRD)and differential scanning calorimetry(DSC).The spray dried lactose particles were spherical and amorphous,but would transfer to crystal form when storage humidity was above 32%.Thus,the humidity of the storage environment should be controlled below 30%strictly in order to maintain the amorphous nature of spray dried lactose which is a great benefit to DPI development.

关 键 词：Spray drying LACTOSE CARRIER Dry powder inhalation 

分 类 号：TG1[金属学及工艺—金属学]