A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution  

作　　者：Pornsak Sriamornsak Sontaya Limmatvapirat Suchada Piriyaprasarth Punyanutch Mansukmanee Zongkang Huang 

机构地区：[1]Department of Pharmaceutical Technology,Faculty of Pharmacy,Silpakorn University,Nakhon Pathom 73000,Thailand [2]Pharmaceutical Biopolymer Group(PBiG),Faculty of Pharmacy,Silpakorn University,Nakhon Pathom 73000,Thailand

出　　处：《Asian Journal of Pharmaceutical Sciences》2015年第2期121-127,共7页亚洲药物制剂科学（英文）

基　　金：Financial support from The Thailand Research Fund(grant number BRG5480013)is greatly acknowledged.

摘　　要：To enhance the dissolution of poorly soluble mefenamic acid,self-emulsifying formulation(SEF),composing of oil,surfactant and co-surfactant,was formulated.Among the oils and surfactants studied,Imwitor■ 742,Tween■ 60,Cremophore■ EL and Transcutol■ HP were selected as they showed maximal solubility to mefenamic acid.The ternary phase diagram was constructed to find optimal concentration that provided the highest drug loading.The droplet size after dispersion and drug dissolution of selected formulations were investigated.The results showed that the formulation containing Imwitor■ 742,Tween■ 60 and Transcutol■ HP(10:30:60)can encapsulate high amount of mefenamic acid.The dissolution study demonstrated that,in the medium containing surfactant,nearly 100% of mefenamic acid were dissolved from SEF within 5 min while 80% of drugs were dissolved from the commercial product in 45 min.In phosphate buffer(without surfactant),80% of drug were dissolved from the developed SEF within 5 min while only about 13% of drug were dissolved in 45 min,from the commercial product.The results suggested that the SEF can enhance the dissolution of poorly soluble drug and has a potential to enhance drug absorption and improve bioavailability of drug.

关 键 词：Self-emulsifying formulation Poorly water-soluble drug Mefenamic acid Drug dissolution 

分 类 号：R61[医药卫生—外科学]