老年高血压患者认知功能障碍与ApoA5 IVS3+476G>A基因多态性关系  

The relationship between cognitive dysfunction and ApoA5 IVS3+476G>A gene polymor⁃phism in elderly hypertensive patients

作　　者：施勇 谢月萍 张春丽 SHI Yong;XIE Yueping;ZHANG Chunli(Department of Geriatric Medicine,Nanning First People’s Hospital,Nanning,Guangxi,China,530022)

机构地区：[1]广西医科大学第五附属医院老年医学科,广西南宁530022

出　　处：《分子诊断与治疗杂志》2021年第7期1043-1046,共4页Journal of Molecular Diagnostics and Therapy

基　　金：广西南宁市科学研究与技术开发计划项目资助(201003044C-6)。

摘　　要：目的探究老年高血压患者认知功能障碍与载脂蛋白A5(ApoA5)IVS3+476G>A基因多态性的关系。方法选取2015年7月至2018年7月于本院诊治的90例老年高血压患者且分为老年高血压认知功能障碍组(n=40)和认知正常组(n=50)。利用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术联合国际通用智力状况量表(MMSE)测定患者的ApoA5 IVS3+476G>A基因多态性和认知功能。结果认知障碍组ApoA5多态性基因型频率显著高于正常组ApoA5多态性基因型频率,差异有统计学意义(P<0.05)。认知障碍组ApoA5 IVS3+476G>A等位基因频率与正常组ApoA5 IVS3+476G>A等位基因频率比较,差异有统计学意义(P<0.05)。认知障碍组ApoA5 IVS3+476G>A基因的TT、TC、CC与认知功能障碍呈现出正向相关性(P<0.05),文化程度是影响认知功能障碍的保护因素(P<0.05)。结论载脂蛋白ApoA5 IVS3+476G>A基因影响患者的认知功能,对深入研究高血压患者认知功能障碍有着重要意义。Objective To explore the relationship between cognitive dysfunction in elderly hyper⁃tensive patients and apolipoprotein A5(ApoA5)IVS3+476G>A gene polymorphism.Methods A total of 90 elderly hypertensive patients diagnosed and treated in our hospital from July 2015 to July 2018 were select⁃ed and divided into elderly hypertensive cognitive dysfunction group(n=40)and cognitive normal group(n=50).The polymerase chain reaction⁃restriction fragment length polymorphism(PCR⁃RFLP)technology com⁃bined with the International General Intelligence Status Scale(MMSE)was used to determine the ApoA5 IVS3+476G>A gene polymorphism and cognitive function of patients.Results The frequency of ApoA5 poly⁃morphism genotype in the cognitive impairment group was significantly higher than that in the normal group,and the difference was statistically significant(P<0.05).There is a significant difference of the ApoA5 IVS3+476 G>A allele frequency between the cognitive impairment group and the normal group(P<0.05).Cognitive impairment group of ApoA5 IVS3+476G>A gene TT,TC,CC and cognitive dysfunction shows a positive cor⁃relation(P<0.05).Education level is a protective factor affecting cognitive dysfunction(P<0.05).Conclu⁃sion The ApoA5 IVS3476G>A gene affects the cognitive function of patients,which is of great signifi⁃cance for the in⁃depth study of cognitive dysfunction in patients with hypertension.

关 键 词：老年高血压 认知功能障碍 载脂蛋白A5基因(800)IVS3+476G>A基因多态性 

分 类 号：R544.1[医药卫生—心血管疾病] R749.1[医药卫生—内科学]