IL-17A、sICAM-1及sE-选择素与RA患者疾病活动度及疗效的关系  

The relationship between the levels of IL⁃17A,sICAM⁃1 and sE⁃selectin and disease activity and efficacy in RA patients

作　　者：任占芬[1] 郑学军[1] 罗寰[1] 方晓 李红燕 赵春桃[2] REN Zhanfen;ZHENG Xuejun;LUO Huan;FANG Xiao;Li Hongyan;ZHAO Chuntao(Department of Rheumatology and Immunology,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,China,075000;Department of Ultrasound,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,China,075000)

机构地区：[1]河北北方学院附属第一医院风湿免疫科,河北张家口075000 [2]河北北方学院附属第一医院超声科,河北张家口075000

出　　处：《分子诊断与治疗杂志》2021年第7期1098-1101,1105,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河北省医学科学研究课题计划(20170931)。

摘　　要：目的分析类风湿性关节炎(RA)患者白细胞介素17A(IL-17A)、可溶性细胞间粘附分子-1(sICAM-1)以及可溶性E选择素(sE-选择素)水平变化与疾病活动程度、治疗疗效的关系。方法选取2017年3月至2018年12月本院收治的110例RA患者设为研究组,根据RA患者病情活动度评价表(DAS28)分为低活动度36例,中活动度48例,高活动度26例。另选取同期于本院进行健康检查的65例正常人群作为对照组。比较不同人群IL-17A、sICAM-1、sE-选择素及D-二聚体(D-D)水平,并分析IL-17A、sICAM-1、sE-选择素及D-D水平与疾病活动程度的相关性,采用Logistic回归分析影响RA患者疗效的相关危险因素。结果研究组患者IL-17A、sICAM-1、sE-选择素及D-D水平均明显高于对照组,差异具有统计学意义(P<0.05)。不同疾病活动度患者IL-17A、sICAM-1、sE-选择素及D-D水平:重活动度组>中活动度组>低活动度组,各组间比较差异具有统计学意义(P<0.05)。IL-17A、sICAM-1、sE-选择素及D-D水平与RA患者疾病活动程度呈正相关(P<0.05),与类风湿因子水平无明显相关性(P>0.05)。logistic回归分析结果显示:IL-17A(高水平)、sICAM-1(高水平)、sE-选择素(高水平)、D-D(高水平)为影响RA患者疗效的独立危险因素(P<0.05)。结论 IL-17A、sICAM-1、sE-选择素及D-D在RA患者中显著上升,其异常表达与患者疾病活动度和治疗疗效密切相关,可作为预测患者疗效的有效指标。Objective To analyze the relationship between changes in the levels of interleukin⁃17A(IL⁃17A),soluble intercellular adhesion molecule⁃1(sICAM⁃1)and soluble E⁃selectin(sE⁃selectin)and disease activity and efficacy in patients with rheumatoid arthritis(RA).Methods The 110 RA patients admitted to this hospital from March 2017 to December 2018 were selected as the study group.According to the disease activity score 28(DAS28).they were divided into36 cases with low disease activity,48 cases with moderate disease activity,and 26 cases with high disease activity.In addition,65 normal people who underwent a health check in this hospital during the same period were selected as the control group.The levels of IL⁃17A,sICAM⁃1,sE⁃selectin and D⁃Dimer(D⁃D)in different people were compared,and the correlation between the levels of IL⁃17A,sICAM⁃1,sE⁃selectin and D⁃D and the disease activity was analyzed,and the logistic regression analysis was used to analyze the related risk factors affecting the curative effect of RA patients.Results The levels of IL⁃17A,sICAM⁃1,sE⁃selectin and D⁃D in the study group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05). The levels of IL⁃17A, sICAM ⁃ 1,sE ⁃ selectin and D ⁃ D in patients with different degrees of disease activity were as follows:heavy activity group > medium activity group > low activity group,the differences between the groups were statistically significant(P<0.05). The degrees of disease activity of RA patients were positively correlated with the levels of IL ⁃ 17A,sICAM ⁃ 1,sE ⁃ selectin and D ⁃ D(P<0.05). There was no significant correlation with levels of rheumatoid factors(P>0.05). The logistic regression analysis showed that IL ⁃ 17A(high level),sICAM ⁃ 1 (high level),sE ⁃ selectin (high level) and D ⁃ D (high level) were independent risk factors affecting the efficacy of RA patients (P<0.05). Conclusion IL ⁃ 17A,sICAM ⁃ 1,sE ⁃ selectin and

关 键 词：RA IL-17A SICAM-1 SE-选择素 疾病活动度 疗效 

分 类 号：R593.22[医药卫生—内科学]