Self nano-emulsifying drug delivery system for Embelin:Design,characterization and in-vitro studies  

作　　者：Komal Parmar Jayvadan Patel Navin Sheth 

机构地区：[1]Department of Pharmaceutical Sciences,Saurashtra University,Rajkot,Gujarat 360005,India [2]Nootan Pharmacy College,Visnagar,Gujarat 384315,India

出　　处：《Asian Journal of Pharmaceutical Sciences》2015年第5期396-404,共9页亚洲药物制剂科学（英文）

摘　　要：CThe objective of the present study was to prepare solid self-nanoemulsifying drug delivery system(S-SNEDDS)containing Capryol-90 as oil phase for the delivery of Embelin,a poorly water soluble herbal active ingredient.Box-Behnken experimental design was employed to optimise the formulation variables,X1(amount of oil;Capryol 90),X2(amount of surfactant;Acrysol EL 135)and X3(amount of co-surfactant;PEG 400).Systems were appraised for visual characteristics for self emulsifying time,globule size and drug release.Optimised liquid formulations were formulated into free flowing granules(S-SNEDDS)by adsorption on the porous materials like Aerosil 200 and Neusilin and thereby compressed into tablet.In vitro dissolution studies of SNEDDS revealed increased in the dissolution rate of the drug.FT-IR data revealed no physicochemical interaction between drug and excipients.Solid state characterization of S-SNEDDS by DSC and Powder XRD confirmed reduction in drug crystallinity which further supports the results of dissolution studies.TEM analysis exhibited spherical globules.Further,the accelerated stability studies for 6 months revealed that S-SNEDDS of Embelin are found to be stable without any significant change in physicochemical properties.Thus,the present studies demonstrated dissolution enhancement potential of porous carrier based S-SNEDDS for poorly water soluble herbal active ingredient,Embelin.

关 键 词：EMBELIN SNEDDS Dissolution enhancement Box-Behnken design CHARACTERIZATION 

分 类 号：O64[理学—物理化学]