灯盏花素对脑卒中患者的神经功能以及血清FGF4、TAFI因子水平的影响  

Effects of breviscapine on neurological function and serum FGF4,TAFI factor levels in stroke patients

作　　者：赵莉芳 赵楠 王振兴 ZHAO Li-fang;ZHAO Nan;WANG Zhen-xing(Department of Internal Medicine,FuYangShi Hospital of TCM,Fuyang Anhui 236000,China)

机构地区：[1]阜阳市中医医院内科,安徽阜阳236000

出　　处：《临床和实验医学杂志》2021年第14期1478-1482,共5页Journal of Clinical and Experimental Medicine

基　　金：阜阳市卫生健康委科研课题(编号:FY2019-055);安徽省医学会临床研究项目(编号:20180047A)。

摘　　要：目的观察灯盏花素对脑卒中患者的神经功能以及血清成纤维细胞生长因子4(FGF4)、凝血酶激活纤溶抑制物(TAFI)因子水平的影响。方法前瞻性选取2017年1月至2019年5月阜阳市中医医院收治的脑卒中患者80例,按照随机数字表法将其分为2组,对照组40例给予常规治疗,观察组40例在常规治疗基础上加用灯盏花素治疗。统计2组患者临床疗效;比较2组患者治疗前、治疗2周后美国国立卫生研究院卒中量表(NIHSS)评分和Spit-zer生活质量指数表(QLI)评分;检测2组患者治疗前、治疗14 d后血清FGF4、TAFI、高敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)、脑血管储备功能(CVR)及大脑中动脉和基底动脉平均血流速度的差别。结果观察组总有效率90.00%,高于对照组的72.50%,差异有统计学意义(P<0.05)。治疗2周后,观察组和对照组的TAFI[(16.85±2.41)、(13.59±2.77)μg/mL]、CVR[(33.58±3.96)%、(24.11±3.27)%]、大脑中动脉平均血流速度[(44.75±4.83)、(36.89±5.14)cm/s]、基底动脉平均血流速度[(37.85±4.05)、(30.72±3.96)cm/s]上升,FGF4[(153.28±24.19)、(174.23±31.56)pg/mL]、hs-CRP[(5.46±1.27)、(7.23±1.84)mg/L]、IL-8[(51.47±8.55)、(68.32±10.12)pg/mL]较治疗前下降,且观察组治疗2周后TAFI、CVR及大脑中动脉和基底动脉平均血流速度较对照组高,FGF4、hs-CRP、IL-8较对照组低,差异均有统计学意义(P<0.05)。治疗2周后,观察组和对照组的QLI评分[(43.25±3.11)、(24.56±4.05)分]较治疗前上升,NIHSS评分[(7.25±1.03)、(8.87±1.45)分]较治疗前下降,且观察组治疗2周后QLI评分较对照组高,NIHSS评分较对照组低,差异均有统计学意义(P<0.05)。结论灯盏花素治疗脑卒中可调节血清FGF4、TAFI、hs-CRP、IL-8的表达,改善脑血管储备功能和神经功能,提高疗效和生活质量。Objective To observe the effect of breviscapine on nerve function and serum fibroblast growth factor 4(FGF4)and thrombin activated fibrinolytic inhibitor(TAFI)in stroke patients.Methods A total of 80 stroke patients admitted to Fuyang Hospital of TCM from January 2017 to May 2019 were prospectively selected and randomly divided into two groups according to the random number table method.Forty cases in the control group were treated with routine treatment,and 40 cases in the observation group were treated with breviscapine on the basis of conventional treatment.To compare the scores of stroke scale(NIHSS)and Spit-zer quality of life index(QLI)before treatment,after 2 weeks of treatment between the two groups,the difference of mean blood flow velocity between the two groups FGF4,TAFI,high-sensitivity C-reactive protein(hs-CRP),interleukin-8(IL-8),cerebro vascular reserve function(CVR)and middle cerebral artery and basilar artery before treatment,after 2 weeks of treatment were detected.Results After 2 weeks of treatment,the total effective rate of the observation group was 90.00%,which was higher than 72.50% of the control group,and the difference was statistically significant(P<0.05).After 2 weeks of treatment,TAFI[(16.85±2.41),(13.59±2.77)μg/mL],CVR[(33.58±3.96)%,(24.11±3.27)%],mean flow velocity in middle cerebral artery[(44.75±4.83),(36.89±5.14)cm/s],mean flow velocity of basilar artery[(37.85±4.05),(30.72±3.96)cm/s]in observation group and control group were higher than before treatment,while FGF4[(153.28±24.19),(174.23±31.56)pg/mL],hs-CRP[(5.46±1.27),(7.23±1.84)mg/L]and IL-8[(51.47±8.55),(68.32±10.12)pg/mL]were lower than before treatment.In addition,TAFI,CVR and mean flow velocity in middle cerebral artery and mean flow velocity of basilar artery in the observation group were higher than those in the control group,and FGF4,hs-CRP and IL-8 were lower than those in the control group,the differences were statistically significant(P<0.05).After 2 weeks of treatment,the QLI scores[(43.25±3.11),(24

关 键 词：脑卒中 灯盏花素 神经功能 成纤维细胞生长因子4 凝血酶激活纤溶抑制物 疗效 

分 类 号：R277.7[医药卫生—中医学]