结核菌感染T细胞干扰素释放检测在脊柱结核快速诊断中的应用  

Application of t-cell interferon release detection in rapid diagnosis of spinal tuberculosis in patients with tuberculosis

作　　者：张敏 蔡灼远 于莉 ZHANG Min;CAI Zhuo-yuan;YU Li(Department of Clinical Laboratory,Danzhou People's Hospital,Danzhou Hainan 571700,China)

机构地区：[1]儋州市人民医院检验科,海南儋州571700

出　　处：《临床和实验医学杂志》2021年第14期1521-1524,共4页Journal of Clinical and Experimental Medicine

基　　金：海南省卫生和计划生育委员会科研项目(编号:1801032034A2005)。

摘　　要：目的研究结核菌感染T细胞干扰素释放检测(T-SPOT.TB)在脊柱结核快速诊断中的应用价值。方法回顾性选取2019年1月至2020年1月儋州市人民医院入院的49例疑似脊柱结核患者作为研究对象,所有患者均开展抗结核抗体检测、结核菌素试验、T-SPOT.TB,比较不同检测方法诊断脊柱结核的敏感度、特异度、阴性预测值、阳性预测值。结果结核菌素试验诊断脊柱结核的敏感度、特异度、阴性预测值、阳性预测值依次为61.29%、72.22%、52.00%、79.17%,抗结核抗体检测诊断脊柱结核的敏感度、特异度、阴性预测值、阳性预测值依次为70.97%、55.56%、52.63%、73.33%,T-SPOT.TB检测诊断脊柱结核的敏感度、特异度、阴性预测值、阳性预测值依次为93.55%、88.89%、88.89%、93.55%;结核菌素试验、抗结核抗体检测诊断脊柱结核的敏感度、特异度、阴性预测值、阳性预测值比较,差异无统计学意义(P>0.05);与结核菌素试验、抗结核抗体检测比较,T-SPOT.TB诊断脊柱结核的敏感度、特异度、阴性预测值、阳性预测值更高,差异均有统计学意义(P<0.05)。结论脊柱结核快速诊断中T-SPOT.TB检测的应用效果显著,临床诊断的敏感度、特异度、阴性预测值、阳性预测值均高于抗结核抗体检测和结核菌素试验,对脊柱结核诊断准确性高。Objective To study the application value of tuberculosis infection T cell interferon release test(T-SPOT.TB)in the rapid diagnosis of spinal tuberculosis.Methods From January 2019 to January 2020,49 patients with suspected spinal tuberculosis admitted to the Danzhou People's Hospital were retrospectively selected as the research objects.All patients were tested for anti-tuberculosis antibody,tuberculin test,T-SPOT.TB,and the sensitivity,specificity,negative predictive value,and positive predictive value of different detection methods for the diagnosis of spinal tuberculosis were compared.Results The sensitivity,specificity,negative predictive value,and positive predictive value of tuberculin test for the diagnosis of spinal tuberculosis were 61.29%,72.22%,52.00%,and 79.17%.The sensitivity,specificity,and negative of anti-tuberculosis antibody test for diagnosis of spinal tuberculosis were 61.29%,72.22%,52.00%,and 79.17%.The predictive value and the positive predictive value were 70.97%,55.56%,52.63%,and 73.33%.The sensitivity,specificity,negative predictive value,and positive predictive value of the T-SPOT.TB test for the diagnosis of spinal tuberculosis were 93.55%and 88.89%,respectively,88.89%,93.55%;There was no significant difference in the sensitivity,specificity,negative predictive value,and positive predictive value of tuberculin test and anti-tuberculosis antibody detection in the diagnosis of spinal tuberculosis(P>0.05).Compared with tuberculin test and anti-tuberculosis antibody detection,T-SPOT.TB had higher sensitivity,specificity,negative predictive value,and positive predictive value in the diagnosis of spinal tuberculosis,and the difference was statistically significant(P<0.05).Conclusion The application effect of T-SPOT.TB test in the rapid diagnosis of spinal tuberculosis is remarkable.The sensitivity,specificity,negative predictive value and positive predictive value of clinical diagnosis are all higher than the anti-tuberculosis antibody test and tuberculin test,and the diagnosis of spinal tube

关 键 词：脊柱结核 抗结核抗体 结核菌素试验 结核菌感染T细胞 干扰素 

分 类 号：R529.2[医药卫生—内科学]