LC–MS-based metabolomics in profiling of drug metabolism and bioactivation  

作　　者：Feng Li Frank JGonzalez Xiaochao Ma 

机构地区：[1]Department of Pharmacology,Toxicology and Therapeutics,University of Kansas Medical Center,Kansas City,Kansas 66160,USA [2]Laboratory of Metabolism,Center for Cancer Research,National Cancer Institute,National Institutes of Health,Bethesda,Maryland 20892,USA

出　　处：《Acta Pharmaceutica Sinica B》2012年第2期118-125,共8页药学学报（英文版）

摘　　要：Since metabolism significantly affects drug safety and efficacy,determining the metabolic profile of a drug is a critical part of drug development.The application of an LC–MS-based metabolomic approach has gained more widespread use in identifying drug metabolites,developing metabolic maps and lending clues to mechanisms of bioactivation.Thus,the LC–MS-based metabolomic approach is a powerful tool for profiling of drug metabolism and bioactivation.

关 键 词：Metabolomics Drug metabolism Reactive metabolites Multivariate data analysis 

分 类 号：R96[医药卫生—药理学]