益血生胶囊联合琥珀酸亚铁治疗妊娠贫血的疗效观察  

Clinical observation of Yixuesheng Capsules combined with ferrous succinate in treatment of pregnancy anemia

作　　者：赵琳[1] 李虹[1] 崔英 ZHAO lin;LI Hong;CUI Ying(Department of Obstetrics,Tianjin First Central Hospital,Tianjin 300192,China;Department of Neurology,Tianjin Huanhu Hospital,Tianjin 300211,China)

机构地区：[1]天津市第一中心医院产科,天津300192 [2]天津市环湖医院神经内科,天津300211

出　　处：《现代药物与临床》2021年第6期1186-1189,共4页Drugs & Clinic

基　　金：天津市教委科研计划项目(2018KJ009)。

摘　　要：目的探讨益血生胶囊联合琥珀酸亚铁片治疗妊娠贫血的临床疗效。方法选取2019年6月—2020年12月天津市第一中心医院收治的100例妊娠贫血患者,按照随机数字表法将所有患者分为对照组和治疗组,每组各50例。对照组口服琥珀酸亚铁片,200 mg/次,2次/d。治疗组在对照组基础上口服益血生胶囊,4粒/次,2次/d。两组患者连续治疗1个月。观察两组的总有效率,比较两组患者治疗前后血清血红蛋白、转铁蛋白受体、铁蛋白水平以及不良妊娠发生情况。结果治疗后,治疗组患者的总有效率(90.00%)明显高于对照组(74.00%),差异有统计学意义(P<0.05)。治疗后,两组的血红蛋白、转铁蛋白受体、铁蛋白水平显著升高,差异有统计学意义(P<0.05);治疗组的血红蛋白、转铁蛋白受体、铁蛋白水平比对照组高,差异有统计学意义(P<0.05)。治疗组不良妊娠结局的发生率(8.00%)明显低于对照组(22.00%),差异有统计学意义(P<0.05)。结论益血生胶囊联合琥珀酸亚铁片可提高妊娠贫血的临床疗效,调节血红蛋白、转铁蛋白受体、铁蛋白水平,降低不良妊娠结局的发生。Objective To investigate the effect of Yixuesheng Capsules combined with Ferrous Succinate Tablets in treatment of pregnancy anemia.Methods Patients(100 cases)with pregnancy anemia in Tianjin First Central Hospital from June 2019 to December 2020 were randomly divided into control and treatment groups,and each group had 50 cases.Patients in the control group were po administered with Ferrous Succinate Tablets,200 mg/time,twice daily.Patients in the treatment group were po administered with Yixuesheng Capsules on the basis of the control group,4 grains/time,twice daily.Patients in two groups were treated for 1 month.After treatment,the clinical efficacies were evaluated,and the serum levels of hemoglobin,transferrin receptor,ferritin,and the occurrence of adverse pregnancy were compared before and after treatment.Results After treatment,the total effective rate of the treatment group(90.00%)was significantly higher than that of the control group(74.00%),and the difference was statistically significant(P<0.05).After treatment,the serum levels of hemoglobin,transferrin receptor,and ferritin in two groups were significantly increased(P<0.05).The serum levels of hemoglobin,transferrin receptor,and ferritin in the treatment group were higher than those in the control group(P<0.05).The incidence of adverse pregnancy outcomes in the treatment group(8.00%)was significantly lower than that in the control group(22.00%),and the difference was statistically significant(P<0.05).Conclusion Yixuesheng Capsules combined with Ferrous Succinate Tablets can improve the clinical efficacy of pregnancy anemia,regulate the levels of hemoglobin,transferrin receptor,and ferritin,and reduce the occurrence of adverse pregnancy outcomes.

关 键 词：益血生胶囊 琥珀酸亚铁片 妊娠贫血 血红蛋白 转铁蛋白受体 铁蛋白 不良妊娠结局 

分 类 号：R984[医药卫生—药品]