益血生胶囊联合多糖铁复合物治疗妊娠期缺铁性贫血的临床研究  

Clinical study of Yixuesheng Capsules combined with iron polysaccharide complex in treatment of iron deficiency anemia during pregnancy

作　　者：王娜[1] 陈丽珍[1] 邱雪洲[1] 张小环 张玲[1] WANG Na;CHEN Li-zhen;QIU Xue-zhou;ZHANG Xiao-huan;ZHANG Ling(Department of Obstetrics,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院产科,河南南阳473000

出　　处：《现代药物与临床》2021年第6期1190-1193,共4页Drugs & Clinic

基　　金：河南省科技攻关项目(201702564)。

摘　　要：目的探讨益血生胶囊联合多糖铁复合物胶囊治疗妊娠期缺铁性贫血的临床疗效。方法选取2018年8月—2020年8月在南阳市中心医院进行治疗的158例妊娠期缺铁性贫血患者为研究对象,根据用药差别分为对照组(79例)和治疗组(79例)。对照组口服多糖铁复合物胶囊,0.3 g/次,1次/d;治疗组在对照组基础上口服益血生胶囊,1 g/次,3次/d。两组患者均治疗4周对比临床效果。观察两组的临床疗效,比较两组患者铁代谢指标、血常规指标和血清学指标的变化情况。结果经治疗,治疗组总有效率是98.73%,显著高于对照组的86.08%(P<0.05)。治疗后,两组血清铁蛋白(SF)、血清铁(SI)均增高,但转铁蛋白受体(s TFR)、总铁结合力(TIBC)均显著降低(P<0.05);治疗后,治疗组铁代谢指标改善优于对照组(P<0.05)。治疗后,两组红细胞计数(RBC)、血红蛋白(Hb)、红细胞平均体积(MCV)、平均血红蛋白量(MCH)均较治疗前显著增高(P<0.05);治疗后,治疗组血常规指标改善优于对照组(P<0.05)。治疗后,两组血清白细胞介素2(IL-2)、γ干扰素(INF-γ)、氧磷酶1(PON1)、铁调素-25水平均显著升高(P<0.05);治疗后,治疗组血清学指标改善优于对照组(P<0.05)。结论益血生胶囊联合多糖铁复合物胶囊治疗妊娠期缺铁性贫血效果显著,可有效改善患者贫血状态,改善铁代谢指标和血清细胞因子水平,有着良好的临床应用价值。Objective To investigate the clinical efficacy of Yixuesheng Capsules combined with iron polysaccharide complex in treatment of iron deficiency anemia during pregnancy. Methods A total of 158 patients with iron deficiency anemia during pregnancy who were treated in Nanyang Central Hospital from August 2018 to August 2020 were selected as the research subjects, and they were divided into control group(79 cases) and treatment group(79 cases) according to medication difference. Patients in the control group were po administered with Iron Polysaccharide Complex Capsules, 0.3 g/time, once daily. Patients in the treatment group were po administered with Yixuesheng Capsules on the basis of the control group, 1 g/time, three times daily. Two groups of patients were treated for 4 weeks. The clinical efficacy of the two groups was observed and the changes of iron metabolism indexes, blood routine indexes, and serological indexes were compared between two groups. Results After treatment, the total effective rate of treatment group was 98.73%, which was significantly higher than that of control group(86.08%, P < 0.05). After treatment, SF and SI were increased in both groups, but sTFR and TIBC were significantly decreased(P < 0.05). After treatment, the improvement of iron metabolism in the treatment group was better than that in the control group(P < 0.05). After treatment, the levels of RBC, Hb, MCV, and MCH in two groups were significantly increased compared with before treatment(P < 0.05). After treatment, the improvement of blood routine indexes in treatment group was better than that in control group(P < 0.05). After treatment, the levels of serum IL-2, INF-γ, PON1, and iron-modulin-25 in two groups were significantly increased(P < 0.05). After treatment, the improvement of serological indexes in the treatment group was better than that in the control group(P < 0.05). Conclusion Yixuesheng Capsules combined with iron polysaccharide complex has significantly effective in treatment of iron deficiency anemia during pregn

关 键 词：益血生胶囊 多糖铁复合物胶囊 妊娠期缺铁性贫血 转铁蛋白受体 总铁结合力 红细胞计数 血红蛋白 红细胞平均体积 平均血红蛋白量 

分 类 号：R984[医药卫生—药品]