生血宝颗粒联合乳酸亚铁治疗儿童缺铁性贫血的临床研究  

Clinical study on Shengxuebao Granules combined with ferrous lactate in treatment of iron deficiency anemia in children

作　　者：张世君 徐征 ZHANG Shi-jun;XU Zheng(Department of Hematology,Xinyang Central Hospital,Xinyang 464000,China)

机构地区：[1]信阳市中心医院血液内科,河南信阳464000

出　　处：《现代药物与临床》2021年第6期1199-1202,共4页Drugs & Clinic

基　　金：信阳市市级软科学项目(20190056)。

摘　　要：目的探讨生血宝颗粒联合乳酸亚铁片治疗儿童缺铁性贫血的临床疗效。方法选取2019年9月—2020年11月在信阳市中心医院就诊的86例缺铁性贫血患儿作为研究对象,按照随机数字表法将86例患者分为对照组和治疗组,每组各43例。对照组口服乳酸亚铁片,0.1g/次,3次/d。治疗组在对照组治疗基础上温水冲服生血宝颗粒,8g/次,2次/d。两组患儿连续治疗8周。观察两组临床疗效,比较两组治疗前后的世界卫生组织生存质量测定量表简表(WHOQOL-BREF)评分、红细胞指标和铁代谢指标。结果治疗后,治疗组患者的总有效率为95.35%,对照组为81.40%,组间比较差异有统计学意义(P<0.05)。治疗后,两组的WHOQOL-BREF评分显著升高(P<0.05),以治疗组WHOQOL-BREF评分升高更明显(P<0.05)。治疗后,两组的红细胞计数、血红蛋白、网织红细胞显著升高(P<0.05);治疗后治疗组的红细胞计数、血红蛋白、网织红细胞比对照组高,差异有统计学意义(P<0.05)。治疗后,两组铁、铁蛋白(SF)、转铁蛋白饱和度(TS)水平显著升高(P<0.05);治疗后,治疗组患者的铁、SF、TS水平高于对照组,差异有统计学意义(P<0.05)。结论生血宝颗粒联合乳酸亚铁片治疗缺铁性贫血的疗效确切,能提高患儿的生活质量,改善红细胞水平和铁代谢水平。Objective To explore the clinical study of Shengxuebao Granules combined with Ferrous Lactate Tablets in treatment of iron deficiency anemia in children.Methods Children(86 cases)with iron deficiency anemia in Xinyang Central Hospital from September 2019 to November 2020 were randomly divided into control and treatment groups,and each group had 43 cases.Children in the control group were po administered with Ferrous Lactate Tablets,0.1 g/time,three times daily.Children in the treatment group were po administered with Shengxuebao Granules on the basis of the control group,0.8 g/time,twice daily.Children in two groups were treated for 8 weeks.After treatment,the clinical efficacies were evaluated,and WHOQOL-BREF score,red blood cell index,and iron metabolism index in two groups were compared before and after treatment.Results After treatment,the total effective rate of the treatment group was 95.35%,and that of the control group was 81.40%,and the difference was statistically significant(P<0.05).After treatment,the WHOQOL-BREF scores of two groups was significantly increased(P<0.05),and the WHOQOL-BREF score in the treatment group was significantly higher than that of the control group(P<0.05).After treatment,the red blood cell count,hemoglobin,and reticulocyte of two groups were significantly increased(P<0.05).After treatment,the red blood cell count,hemoglobin,and reticulocyte of the treatment group were higher than those of the control group(P<0.05).After treatment,the levels of iron,SF,and TS in two groups were significantly increased(P<0.05).After treatment,the levels of iron,SF,and TS in the treatment group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Shengxuebao Granules combined with Ferrous Lactate Tablets has curative effect in the treatment of iron deficiency anemia,can improve the level of red blood cell and iron metabolism,improve the quality of life of children.

关 键 词：生血宝颗粒 乳酸亚铁片 儿童缺铁性贫血 WHOQOL-BREF评分 铁蛋白 

分 类 号：R985[医药卫生—药品]