骨愈灵胶囊联合唑来膦酸治疗绝经后骨质疏松症的临床研究  

Clinical study on Guyuling Capsules combined with zoledronic acid in treatment of postmenopausal osteoporosis

作　　者：杨通宝[1] 李翔[1] 鲁俊杰[1] YANG Tong-bao;LI Xiang;LU Jun-jie(Department of Orthopaedics,Zhengzhou Orthopedic Hospital,Zhengzhou 450052,China)

机构地区：[1]郑州市骨科医院骨科,河南郑州450052

出　　处：《现代药物与临床》2021年第6期1236-1240,共5页Drugs & Clinic

基　　金：河南省医学科技攻关计划项目(2017T02193)。

摘　　要：目的观察骨愈灵胶囊联合唑来膦酸注射液治疗绝经后骨质疏松症的临床疗效。方法选取2018年3月—2020年9月郑州市骨科医院接收的60例绝经后骨质疏松症患者,根据奇偶顺序将所有患者分为对照组和治疗组,每组各30例。对照组静脉滴注唑来膦酸注射液,将5 mg唑来膦酸注射液溶入100 mL生理盐水中,每3~4周给药1次。治疗组在对照组治疗的基础上口服骨愈灵胶囊,5粒/次,3次/d。两组患者均连续治疗3个月。观察两组疗效,对比两组治疗前后的腰椎正位(L1-4)和左股骨颈的骨密度、视觉模拟疼痛评分法(VAS)评分、WHO生存质量测定量表简表(WHOQOL-BREF)评分、骨代谢指标。结果治疗后,治疗组的总有效率(93.33%)高于对照组(66.67%),两组比较差异有统计学意义(P<0.05)。治疗后,两组腰椎正位(L1-4)、左股骨颈的骨密度较治疗前升高(P<0.05),且治疗组腰椎正位(L1-4)、左股骨颈的骨密度较对照组高(P<0.05)。治疗后,两组VAS评分降低,心理状态评分、社会关系评分、生理功能评分、环境评分较治疗前升高(P<0.05),且治疗组VAS评分较对照组低,心理状态评分、社会关系评分、生理功能评分、环境评分均较对照组高(P<0.05)。治疗后,两组骨钙素(BGP)、人骨碱性磷酸酶(BALP)水平均显著升高,I型胶原交联羧基末端肽(CTX-I)水平较治疗前下降(P<0.05),且治疗组BGP、BALP水平高于对照组,CTX-I水平较对照组低,差异有统计学意义(P<0.05)。两组血钙离子(Ca^(2+))组间比较无统计学差异。结论骨愈灵胶囊联合唑来膦酸注射液治疗绝经后骨质疏松症,可促进症状缓解,有效改善骨代谢指标,阻止骨质疏松症疾病进展,提高患者生活质量。Objective To observe the clinical efficacy of Guyuling Capsules combined with Zoledronic Acid Injection in treatment of postmenopausal osteoporosis.Methods Patients(60 cases)with postmenopausal osteoporosis in Zhengzhou Orthopedic Hospital from March 2018 to September 2020 were randomly divided into control and treatment groups,and each group had 30 cases.Patients in the control group were iv administered with Zoledronic Acid Injection,5 mg added into normal saline 100 mL,once every 3—4 weeks.Patients in the treatment group were po administered with Guyuling Capsules on the basis of the control group,5 grains/time,three times daily.Patients in two groups were treated for 3 months.After treatment,the clinical efficacies were evaluated,and the bone mineral density of lumbar vertebrae(L1-4)and left femoral neck,VAS scores,WHOQOL-BREF scores,bone metabolism indexes in two groups were compared.Results After treatment,the total effective rate of the treatment group(93.33%)was higher than that of the control group(66.67%),and the difference was statistically significant(P<0.05).After treatment,the bone mineral density of lumbar spine(L1-4)and left femoral neck in two groups were higher than that before treatment(P<0.05),and the bone mineral density of lumbar spine(L1-4)and left femoral neck in the treatment group was higher than that in the control group(P<0.05).After treatment,the VAS scores of two groups were decreased,and the scores of psychological state,social relationship,physiological function,and environment in two groups were increased(P<0.05).And the VAS scores of the treatment group was lower than that of the control group,and the scores of psychological state,social relationship,physiological function,and environment of the treatment group were higher than those of the control group(P<0.05).After treatment,the levels of BGP and BALP in two groups were significantly higher than those before treatment,but the levels of CTX-I in two groups were lower than that before treatment(P<0.05).And the levels of BGP an

关 键 词：骨愈灵胶囊 唑来膦酸注射液 绝经后骨质疏松症 骨密度 VAS评分 WHOQOL-BREF评分 骨代谢指标 

分 类 号：R977[医药卫生—药品]