血尿酸与慢性阻塞性肺疾病预后因素相关性的研究进展  

Research progress on correlation between blood uric acid and prognostic factors of chronic obstructive pulmonary disease

作　　者：王娟 王晓宇 郭倩 兀威[1] Wang Juan;Wang Xiaoyu;Guo Qian;Wu Wei(Department of Respiratory Medicine,the Second Affiliated Hospital of Xi′an Medical College,Xi′an 710038,China;Xi′an Medical College,Xi′an 710068,China)

机构地区：[1]西安医学院第二附属医院呼吸内科,710038 [2]西安医学院,710068

出　　处：《国际呼吸杂志》2021年第13期1029-1032,共4页International Journal of Respiration

基　　金：陕西省呼吸病预防与诊治工程研究中心开放基金项目(2018GCKF03)。

摘　　要：慢性阻塞性肺疾病(COPD)是呼吸系统一种十分常见的、并且可以预防和治疗的疾病,其主要特征是持续存在的呼吸系统症状和气流受限。COPD是一种全身性疾病,常伴有多种并发症,包括营养不良、骨质疏松、代谢综合征等,预后因素众多,包括年龄、体质量指数、炎症反应轻重程度以及合并症等,近年来研究发现,尿酸在COPD的病程发展及预后中发挥重要作用,血尿酸是嘌呤代谢的终产物,与COPD的关系密切相关,其参与多种病理生理过程,如氧化-抗氧化、炎症、营养不良、骨质疏松等,涉及各系统的疾病,如肾病、肝病、糖尿病、心脑血管疾病等,参与的呼吸系统疾病主要有COPD、哮喘、肺间质纤维化、阻塞性睡眠呼吸暂停低通气综合征、肺部感染、肺癌等,本文主要阐述尿酸与COPD预后因素的相关性。Chronic obstructive pulmonary disease(COPD)is a very common,preventable and treatable disease of the respiratory system.Its main characteristics are persistent respiratory symptoms and airflow limitation.COPD is a systemic disease,often accompanied by a variety of complications,including malnutrition,osteoporosis,metabolic syndrome,etc.And there are many prognostic factors,including age,body mass index,severity of inflammation,and comorbidities.Recent many studies find that uric acid plays an important role in the development and prognosis of COPD.Serum uric acid is the end product of purine metabolism and is closely related to COPD.It is involved in a variety of pathophysiological processes,such as oxidation-antioxidation,inflammation,and malnutrition,osteoporosis,etc.These diseases include various systems,such as kidney disease,liver disease,diabetes,cardiovascular and cerebrovascular diseases,etc.The respiratory system diseases mainly include COPD,asthma,pulmonary fibrosis,obstructive sleep apnea,hypopnea syndrome,lung infection,lung cancer,etc.This article mainly elaborates the correlation between uric acid and the prognostic factors of COPD.

关 键 词：肺疾病 慢性阻塞性 尿酸 

分 类 号：R563.9[医药卫生—呼吸系统]