血细胞分析仪室内质控方案的设定及分析  

Setting and analysis of internal quality control scheme of blood cell analyzer

作　　者：薛晓兴 刘培培[1] 任爽[1] 李兴翠[1] 李绵洋[1] 王成彬[1] XUE Xiaoxing;LIU Peipei;REN Shuang;LI Xingcui;LI Mianyang;WANG Chengbin(Medical Laboratory Center,First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心医学检验中心,北京100853

出　　处：《国际检验医学杂志》2021年第15期1793-1796,1801,共5页International Journal of Laboratory Medicine

基　　金：国家自然科学基金国家重大科研仪器研制项目(61827806)。

摘　　要：目的采用合适的方法设定质量控制(简称质控)靶值和控制限,保证血细胞分析仪检测结果的可靠性,减少室内质控假失控的现象。方法在保证仪器准确度和正确度的前提下,该文分别采用了3 d 10点定值法、23 d 30点定值法和时间曲线拟合定值法这3种不同方法设定L-J质控图中心线,并比较其优劣。结果3 d 10点定值法绘制L-J质控图中的白细胞计数(WBC)、红细胞计数(RBC)、血红蛋白(Hb)、血小板计数(PLT)、红细胞平均血红蛋白含量(MCH)结果稳定,而3 d 10点定值法和23 d 30点定值法绘制L-J质控图中的红细胞平均体积(MCV)、血细胞比容(HCT)、红细胞平均血红蛋白浓度(MCHC)项目出现较多假失控现象,但用时间曲线拟合定值法绘制L-J质控图中的MCV、HCT、MCHC失控现象明显少见。结论3 d 10点质控值均值作为L-J质控图中的WBC、RBC、Hb、PLT、MCH中心线质控结果稳定,而时间曲线拟合定值法可以良好地制订MCV、HCT、MCHC质控图中心线,符合全血细胞分析质控品特性,可以有效避免假失控,能更好地监测仪器稳定性。Objective To adopt the appropriate method to set the quality control target values for ensuring the detection reliability of blood cells analyzer and reducing the false uncontrolled phenomenon of internal quality control.Methods Under the premise of ensuring the instrument accuracy and trueness,three different methods were adopted:the fixed value method of 10 points on 3 d,fixed value method of 30 points on 23 d and the fitting fixed value method of time curve were used to set the center line of L-J quality control chart and their advantages and disadvantages were compared among them.Results The results of WBC,RBC,Hb,PLT,MCH of RBC in the L-J quality control chart drawn by the fixed value method of 10 points on 3 d were stable,while there were many false uncontrolled phenomena in the items of MCV,HCT and MCHC in the L-J quality control chart drawn by the fixed value methods of 10 points on 3 d and 30 points on 23 d,but the false uncontrolled phenomena of MCV,HCT and MCHC in the L-J quality control chart drawn by the fitting fixed value method of time curve was obviously rare.Conclusion The average value of 3 d 10 points quality control values serves as the central line of WBC,RBC,Hb,PLT,MCH in the L-J quality control chart,the quality control results are stable,and the time curve fitting fixed value can be better used to formulate the center line of MCV,HCT,MCHC quality control chart,which conforms to the characteristics of whole blood cell analysis quality control material,can effectively avoid the false out of control,can better monitor the stability of the instrument.

关 键 词：血细胞分析仪 室内质控 L-J质控图 可靠性 

分 类 号：R446.1[医药卫生—诊断学]