血清半乳糖凝集素-3水平预测急性非ST段抬高型心肌梗死患者心房颤动的价值  

The Value on Serum Galectin-3 Levels in Predicting Atrial Fibrillation in Patientswith Acute Non ST Segment Elevation Myocardial Infarction

作　　者：高曙光 耿国英[1] 韩文杰[1] GAO Shuguang;GENG Guoying;HAN Wenjie(Department of Cardiology,Zhengzhou People’s Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州人民医院心内科,河南郑州450000

出　　处：《河南医学研究》2021年第18期3325-3328,共4页Henan Medical Research

摘　　要：目的分析血清半乳糖凝集素-3(Galectin-3)水平预测急性非ST段抬高型心肌梗死(NSTEMI)患者心房颤动(AF)的价值。方法回顾性分析郑州人民医院2018年10月至2020年10月收治的120例NSTEMI患者临床资料。住院期间心电图持续监测,记录AF发生情况,根据监测结果分为AF组与非AF组,比较两组血清Galectin-3水平和一般临床资料,经logistics回归分析并绘制受试者工作(ROC)曲线分析血清Galectin-3水平预测NSTEMI患者AF的价值。结果 120例患者住院期间发生AF为32例,占26.67%(32/120),非AF为88例,占73.33%(88/120);AF组血清Galectin-3水平高于非AF组,差异有统计学意义(P<0.05),两组患者其他基线资料比较,差异无统计学意义(P>0.05);经logistics回归分析结果显示,血清Galectin-3水平高表达是NSTEMI患者发生AF的影响因子(OR>1,P<0.05);ROC曲线显示,血清Galectin-3水平预测NSTEMI发生AF的曲线下面积(AUC)为0.816(>0.7),根据最佳临界值,其灵敏度、特异度较高,为0.853、0.647,具有一定的预测价值。结论血清Galectin-3水平在NSTEMI合并AF患者中呈高表达,通过检测血清Galectin-3水平可预测NSTEMI发生AF的情况,且血清Galectin-3>9.150μg·L^(-1)时其发生AF的风险较高,临床工作者可针对性进行干预。Objective To analyze the value of serum Galactoselectin-3(Galectin-3)level in predicting atrial fibrillation(AF)in patients with acute non ST segment elevation myocardial infarction(NSTEMI).Methods The clinical data of 120 patients with NSTEMI treated in Zhengzhou People’s Hospital from October 2018 to October 2020 were retrospectively analyzed.Electrocardiogram was monitored continuously during hospitalization,and the occurrence of AF was recorded.They were divided into AF group and non AF group according to the monitoring results.Serum Galectin-3 levels and general clinical data were compared between the two groups.The value of serum galectin-3 level in predicting AF in NSTEMI patient was analyzed by logistics regression analysis and receiver operation(ROC)curve.Results Among 120 patients during hospitalization,32 had AF,accounting for 26.67%(32/120),88 did not have AF,accounting for 73.33%(88/120).The serum Galectin-3 levels in AF group were higher than that in non AF group,and the difference was statistically significant(P<0.05).There were no statistical significant differences in other baseline data between the two groups(P>0.05).By logistic regression analysis,the results showed that the high expression of serum Galectin-3 was the influencing factor of AF in NSTEMI patients(OR>1,P<0.05).The ROC curve showed that the area under the curve(AUC)of serum Galectin-3 level in predicting AF in NSTEMI was 0.816(>0.7).According to the best critical value,its sensitivity and specificity were higher,namely 0.853 and 0.647,which had certain predictive value.Conclusion Serum Galectin-3 is highly expressed in NSTEMI patients with AF.By the detection of serum Galectin-3 level,the occurrence of AF in NSTEMI can be predicted,and when serum Galectin-3>9.150μg·L^(-1),the risk of AF is higher.Clinical workers can take targeted intervention.

关 键 词：急性非ST段抬高型心肌梗死 血清半乳糖凝集素-3 心房颤动 预测价值 

分 类 号：R543.31[医药卫生—心血管疾病]