齐齐哈尔地区老年幽门螺旋杆菌感染患者治疗现状分析  

Analysis of the treatment status of the elderly patients with helicobacter pylori infection in Qiqihar

作　　者：朱艳萍[1] 刘威 王莹 尹钢 黎原[1] 宋海鹰[1] 李广越 关丽娜 ZHU Yan-ping(The first hospital of Qiqihar,Qiqihar,Heilongjiang,161000,China)

机构地区：[1]齐齐哈尔市第一医院,黑龙江齐齐哈尔161000

出　　处：《齐齐哈尔医学院学报》2021年第12期1044-1046,共3页Journal of Qiqihar Medical University

基　　金：齐齐哈尔市科技局指导项目(SFZD-2019080)。

摘　　要：目的对比分析标准三联疗法和含铋四联疗法根除齐齐哈尔地区老年患者幽门螺旋杆菌(Hp)感染疗效,为本地Hp根除用药方案提供参考依据。方法选择2018年1月—2020年1月本院门诊确诊为Hp感染的240例老年患者作为研究对象,随机数表法分为A组、B组、C组和D组共四组,每组各60例。各组的治疗方法分别为:A组给予克拉霉素+泮托拉唑+甲硝唑;B组给予克拉霉素+泮托拉唑+阿莫西林;C组给予胶体果胶铋+克拉霉素+泮托拉唑+甲硝唑;D组给予胶体果胶铋+克拉霉素+泮托拉唑+阿莫西林,所有患者均治疗14天。治疗过程中记录不良反应,治疗30天后14C呼吸试验检测Hp根除情况。结果四组患者在性别、年龄、病种的比较上均无显著差异(P>0.05)。四组患者根除率比较差异具有统计学意义(P<0.05),其中D组根除率最高(P<0.05)。四组患者在治疗过程中均出现不良反应,但各组不良反应率比较无显著差异(P<0.05)。结论胶体果胶铋、克拉霉素、泮托拉唑、阿莫西林的含铋四联疗法作为齐齐哈尔地区老年Hp患者的根除方案,值得首次根除Hp的老年患者推广选用。Objective To compare the efficacy of standard triple therapy and bismuth-containing quadruple therapy in the eradication of helicobacter pylori(Hp)infection in elderly patients in Qiqihar area,so as to provide reference for local Hp eradication program.Methods A total of 240 elderly patients diagnosed with Hp infection in the outpatient department of Qiqihar first hospital from January 2018 to January 2020 were selected as study subjects and they were randomly divided into four groups according to random number table method,with 60 patients in each group.The treatment program of the four groups were as follows:the program of clarithromycin+pantoprazole+metronidazole was administrated in group A;the scheme of clarithromycin+pantoprazole+amoxicillinwas administrated in group A;the plan of colloidal bismuth pectin+clarithromycin+pantoprazole+metronidazole was administrated in group C;colloidal bismuth pectin+clarithromycin+pantoprazole+amoxicillin scheme was used in group D.All the four groups were treated for 14 days.Adverse reactions were recorded during the treatment,and Hp eradication was detected by 14C respiratory test after 30 days of treatment.Results There were no significant differences in gender,age or disease type among the four groups(P>0.05).The difference of eradication rates among the four groups was statistically significant(P<0.05),and the eradication rate in group D was the highest(P<0.05).Adverse reactions occurred in all four groups during the treatment,but there was no significant difference in the adverse reaction rates among the four groups(P<0.05).Conclusions The bismuth-containing quadruple therapy with colloidal pectin bismuth,clarithromycin,pantoprazole and amoxicillin was taken as the eradication program for elderly patients infected with Hp in Qiqihar area,which was worthy of promotion and selection for the elderly patients who received eradication of Hp for the first time.

关 键 词：齐齐哈尔地区 老年患者 幽门螺旋杆菌 标准三联疗法 含铋四联疗法 

分 类 号：R378.2[医药卫生—病原生物学]