低温等离子下声门上成形术对新生儿喉软化的疗效及预后研究  

Efficacy and prognosis of supraglottic plasty with low-temperature plasma radiofrequency ablation on neonatal laryngomalacia

作　　者：李颖[1] 姜岚[1] 徐艳霞 魏艳艳[1] 王洁[1] 僧东杰 张杰[2] LI Ying;JIANG Lan;XU Yanxia;WEI Yanyan;WANG Jie;SENG Dongjie;ZHANG Jie(Department of Otolaryngology Head and Neck Surgery,Children's Hospital Affiliated of Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,Henan,450000,China;Department of Otolaryngology Head and Neck Surgery,National Center for Children's Health,Beijing Children's Hospital,Capital Medical University,Beijing,100045,China)

机构地区：[1]郑州大学附属儿童医院河南省儿童医院郑州儿童医院耳鼻咽喉头颈外科,河南450000 [2]国家儿童医学中心首都医科大学附属北京儿童医院耳鼻咽喉头颈外科,北京100045

出　　处：《中国耳鼻咽喉头颈外科》2021年第6期379-382,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：河南省医学科技攻关计划项目(201702325)。

摘　　要：目的探讨低温等离子下声门上成形术在新生儿喉软化治疗中的效果。方法选取2014年1月~2019年6月郑州大学附属儿童医院治疗的重度喉软化新生儿103例,根据最终选取的治疗方案分为观察组(n=48)和对照组(n=55),观察组给予低温等离子下声门上成形术,对照组给予保守治疗,观察两组治愈率等。结果观察组治疗1、3、6个月后治愈率分别为66.67%、100%和100%,明显高于对照组(P<0.05);体重分别为(5.45±0.64)kg、(6.22±0.80)kg和(7.22±0.89)kg,明显高于对照组(P<0.05);最低血氧饱和度分别为(90.10±4.22)%、(93.56±3.03)%和(95.50±2.00)%,明显高于对照组(P<0.05);观察组治疗1个月、3个月和6个月后食管括约肌静息压分别为(2.30±0.70)kPa、(2.35±0.79)kPa和(2.87±0.80)kPa,蠕动性收缩比分别为(68.98±7.11)%、(72.15±8.03)kPa和(76.68±8.90)kPa,明显高于对照组(P<0.05)。结论低温等离子下声门上成形术治疗新生儿喉软化有较好的效果,其治愈率高,改善患儿生长发育。OBJECTIVE To explore the efficacy of supraglottic plasty with low-temperature plasma radio frequency ablation in the treatment of neonatal laryngomalacia.METHODS A total of 103 newborns with severe laryngomalacia treated in our hospital were selected between January 2014 and June 2019,and were divided into observation group(n=48)and control group(n=55)according to the final treatment plan.The observation group was treated with supraglottic plasty using low-temperature plasma radiofrequency ablation,and the control group was treated with conservative treatment.The cure rate of the two groups was compared.RESULTS The cure rates of the observation group after 1 month,3 months and 6 months of treatment were 66.67%,100%and 100%,which were significantly higher than those of the control group(P<0.05).The body weights of(5.45±0.64)kg,(6.22±0.80)kg and(7.22±0.89)kg were significantly heavier than those of the control group(P<0.05).The lowest blood oxygen saturation values of(90.10±4.22)%,(93.56±3.03)%and(95.50±2.00)%in the observation group were significantly higher than those in the control group(P<0.05).After 1 month,3 months and 6 months of treatment,the esophageal sphincter resting pressures were(2.30±0.70)kPa,(2.35±0.79)kPa and(2.87±0.80)kPa,and the peristaltic contraction ratios were(68.98±7.11)%,(72.15±8.03)kPa and(76.68±8.90)kPa in the observation group,which were significantly higher than those in the control group(P<O.O5).CONCLUSION Supraglottic plasty with low-temperature plasma radiofrequency ablation has a good efficacy in the treatment of neonatal laryngomalacia.It has a high cure rate,and can improves the growth and development of the children.

关 键 词：婴儿 新生 治疗结果 预后 喉软化 低温等离子 声门上成形术 

分 类 号：R767.91[医药卫生—耳鼻咽喉科]