替加环素治疗重症社区获得性肺炎的临床疗效探究  

Clinical effect of tigecycline in the treatment of severe community-acquired pneumonia

作　　者：宋爱琳 SONG Ai-lin(Dalian Friendship Hospital,Dalian 116001,China)

机构地区：[1]大连市友谊医院,116001

出　　处：《中国实用医药》2021年第21期109-112,共4页China Practical Medicine

摘　　要：目的分析替加环素治疗重症社区获得性肺炎的临床疗效。方法50例重症社区获得性肺炎患者,采用随机数字表法分为对照组和研究组,每组25例。对照组患者给予头孢哌酮钠舒巴坦钠治疗,研究组给予替加环素治疗。比较两组临床疗效,脓性痰液、咳嗽及浸润阴影或间质性病变消失时间,炎症指标(降钙素原、肿瘤坏死因子-α、白细胞计数和超敏C反应蛋白)及收缩压、氧合指数。结果研究组治疗总有效率为96.00%,高于对照组的72.00%,差异有统计学意义(P<0.05)。研究组脓性痰液消失时间、咳嗽消失时间、浸润阴影或间质性病变消失时间分别为(8.21±0.15)、(8.25±1.34)、(10.21±2.14)d,短于对照组的(10.21±0.24)、(11.21±1.78)、(13.25±2.55)d,差异有统计学意义(P<0.05)。治疗前,两组白细胞计数、超敏C反应蛋白、降钙素原、肿瘤坏死因子-α、收缩压及氧合指数比较差异无统计学意义(P>0.05);治疗后,两组白细胞计数、超敏C反应蛋白、降钙素原、肿瘤坏死因子-α水平均低于治疗前,收缩压及氧合指数均高于治疗前,且研究组白细胞计数、超敏C反应蛋白、降钙素原、肿瘤坏死因子-α水平均低于对照组,收缩压及氧合指数均高于对照组,差异有统计学意义(P<0.05)。结论替加环素对于重症社区获得性肺炎的治疗效果确切,可有效控制患者机体炎症,并改善血气分析指标和生命体征,值得推广和应用。Objective To analyze the clinical efficacy of tigecycline in the treatment of severe community-acquired pneumonia.Methods A total of 500 patients with severe community-acquired pneumonia were divided into control group and research group according to random numerical table,with 25 cases in each group.The control group was treated with cefoperazone sodium and sulbactam sodium,and the research group was treated with tigecycline.The clinical efficacy,disappearance time of purulent sputum,cough and infiltrating shadows or interstitial lesions,inflammation indicators(procalcitonin,tumor necrosis factor-α,white blood cells counts and high-sensitivity C-reactive protein),systolic blood pressure,oxygenation index were compared between the two groups.Results The total effective rate of the research group was 96.00%,which was higher than 72.00%of the control group,and the difference was statistically significant(P<0.05).The disappearance time of purulent sputum,cough and infiltrating shadows or interstitial lesions of the research group were(8.21±0.15),(8.25±1.34)and(10.21±2.14)d,which were shorter than(10.21±0.24),(11.21±1.78)and(13.25±2.55)d of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in white blood cells counts,high-sensitivity C-reactive protein,procalcitonin,tumor necrosis factor-α,systolic blood pressure,oxygenation index between the two groups(P>0.05).After treatment,the white blood cells counts,high-sensitivity C-reactive protein,procalcitonin and tumor necrosis factor-αof the two groups were lower than those before treatment,and the systolic blood pressure and oxygenation index were higher than those before treatment;the white blood cells counts,high-sensitivity C-reactive protein,procalcitonin and tumor necrosis factor-αof the research group were lower than those of the control group,and the systolic blood pressure and oxygenation index were higher than those of the control group.All the difference was s

关 键 词：替加环素 重症社区获得性肺炎 头孢哌酮钠舒巴坦钠 

分 类 号：R563.1[医药卫生—呼吸系统]