过敏性鼻炎患者血清白细胞介素8、白细胞介素22和肿瘤坏死因子-α水平的变化及其与病情严重程度的关系  

Changes of serum interleukin-8,interleukin-22 and tumor necrosis factor-αlevels in patients with allergic rhinitis and their relationship with the severity of disease

作　　者：田双双 李钦[2] TIAN Shuangshuang;LI Qin(Clinical Medicine School,Qingdao University,Shandong Province,Qingdao266003,China;Department of Otolaryngology,Head and Neck Surgery,Linyi People’s Hospital,Shandong Province,Linyi276000,China)

机构地区：[1]青岛大学临床医学院,山东青岛266003 [2]山东省临沂市人民医院耳鼻喉头颈外科,山东临沂276000

出　　处：《中国医药导报》2021年第21期110-113,共4页China Medical Herald

摘　　要：目的探讨过敏性鼻炎患者血清白细胞介素-8(IL-8)、IL-22及肿瘤坏死因子-α(TNF-α)水平的变化及其与病情严重程度的关系。方法选取2018年1月至2019年12月青岛大学临床医学院(以下简称“我院”)诊治的过敏性鼻炎患者80例为病例组。根据过敏性鼻炎的程度将其分为轻度鼻炎组(31例)和中-重度鼻炎组(49例)。所有患者均接受布地奈德雾化混悬液、孟鲁司特钠片治疗,共治疗12周。另选取同期我院就诊的80名健康志愿者为对照组。比较治疗前、治疗12周后病例组和对照组血清IL-8、IL-22及TNF-α水平;比较不同程度过敏性鼻炎患者的血清IL-8、IL-22、TNF-α水平及过敏性鼻炎评分量表(SFAR)评分;分析血清IL-8、IL-22、TNF-α水平与SFAR评分的相关性。结果治疗前,病例组血清IL-8、IL-22及TNF-α水平均高于对照组,差异均有统计学意义(均P<0.05)。治疗12周后,病例组血清IL-8、IL-22及TNF-α水平低于治疗前,差异均有统计学意义(均P<0.05);病例组IL-8、IL-22及TNF-α水平与对照组比较,差异无统计学意义(P>0.05)。中-重度鼻炎组血清IL-8、IL-22、TNF-α水平高于轻度鼻炎组,差异均有统计学意义(均P<0.05)。中-重度鼻炎组SFAR评分高于轻度鼻炎组,差异有统计学意义(P<0.05)。血清IL-8、IL-22、TNF-α水平与SFAR评分呈正相关(r=0.825、0.737、0.792,P<0.05)。结论过敏性鼻炎患者机体内的血清IL-8、IL-22、TNF-α水平普遍升高,临床上可将其用于过敏性鼻炎的辅助诊断及病情评估。Objective To investigate the changes of serum interleukin-8(IL-8),IL-22 and tumor necrosis factor-α(TNF-α)levels in patients with allergic rhinitis and their relationship with the severity of disease.Methods Eighty patients with allergic rhinitis who diagnosed and treated in Clinical Medicine School,Qingdao University(“our hospital”for short)from January 2018 to December 2019 were selected as the case group.According to the degree of allergic rhinitis,they were divided into mild rhinitis group(31 cases)and moderate-severe rhinitis group(49 cases).All patients received Budesonide Aerosolized Suspension and Montelukast Sodium Tablets,and the treatment lasted for 12 weeks.Another 80 healthy volunteers in our hospital during the same period were selected as the control group.Serum IL-8,IL-22,and TNF-αlevels between the case group and the control group were compared before treatment and 12 weeks after treatment.Serum IL-8,IL-22,TNF-αlevels,and score for allergic rhinitis(SFAR)in patients with different degree of allergic rhinitis were compared and the correlation between serum IL-8,IL-22,TNF-αlevels,and SFAR score were analyzed.Results Before treatment,IL-8,IL-22,and TNF-αlevels in the case group were higher than those in the control group,and the differences were statistically significant(P<0.05).After 12 weeks of treatment,serum IL-8,IL-22,and TNF-αlevels in the case group were lower than those before treatment,and the differences were statistically significant(P<0.05);there was no significant difference in serum IL-8,IL-22,and TNF-αlevels between the case group and the control group(P>0.05).Serum IL-8,IL-22,and TNF-αlevels in moderate-severe rhinitis group were higher than those in mild rhinitis group,and the differences were statistically significant(P<0.05).SFAR score in moderate-severe rhinitis group was higher than that in mild rhinitis group,and the difference was statistically significant(P<0.05).Serum IL-8,IL-22 and TNF-αlevels were positively correlated with SFAR score(r=0.825,0.737,0.792,P<0.

关 键 词：过敏性鼻炎 白细胞介素 肿瘤坏死因子-Α 相关性 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]