新型合成大麻素5F-AB-PINACA、5F-AMB、ABFUBINACA、AMB-FUBINACA的定性检验  

Identification of 5F-AB-PINACA,5F-AMB,AB-FUBINACA and AMB-FUBINACA:Those of Novel Synthetic Cannabinoids

作　　者：赵璟悠 刘超[2] 赵嘉祥 龚丹 杨娅[2] ZHAO Jingyou;LIU Chao;ZHAO Jiaxiang;GONG Dan;YANG Ya(Criminal Police Detachment of Suzhou Public Security Bureau,Suzhou 215000,Jiangsu,China;Evidential Materials Authentication Center of Soochow University,Suzhou 215000,Jiangsu,China)

机构地区：[1]苏州市公安局刑警支队,江苏苏州215000 [2]苏州大学物证鉴定中心,江苏苏州215000

出　　处：《刑事技术》2021年第4期360-364,共5页Forensic Science and Technology

摘　　要：目的利用气相色谱质谱法(GC-MS)、液相色谱质谱法(LC-MS/MS)、傅里叶变换红外光谱法(FTIR)和显微共聚焦拉曼光谱法(RS)建立合成大麻素(5F-AB-PINACA、5F-AMB、AB-FUBINACA、AMB-FUBINACA)的定性检验方法。方法对照品用无水甲醇定容稀释后经GC-MS检测,再用超纯水适当稀释后经LC-MS/MS检测,分别得到对应的质谱图;对照品取少量置于ATR附件和玻璃载玻片分别进行FTIR和RS分析,得到对应的红外光谱图和拉曼光谱图。结果将5F-AB-PINACA和5F-AMB、AB-FUBINACA和AMB-FUBINACA分别作为两组研究对象,经GC-MS和LC-MS/MS检测,每组中两个物质的特征离子碎片峰极为相似,并对其碎裂机制进行简单阐述;经FTIR和RS进一步分析,由于修饰官能团的差别,每组中两个物质的红外吸收峰和拉曼位移峰特异性强、选择性好。结论本文同时采用色谱质谱技术和光谱技术检测分析合成大麻素,检测结果相互确证,为该类物质的鉴定提供数据参考。Objective To de velop a method for identifying 5F-AB-PINACA,5F-AMB,AB-FUBINACA and AMBFUBINACA of novel synthetic cannabinoids(SCs)through approaches of GC-MS,LC-MS/MS,FTIR(Fourier transform infrared spectroscopy)and RS(Raman spectroscopy).Methods GC-MS was adopted to analyze the methanol-dissolved reference substance(enclosing 5F-AB-PINACA,5F-AMB,AB-FUBINACA and AMB-FUBINACA)that was further diluted with ultra-pure water for LC-MS/MS analysis.For FTIR and RS analysis,a small quantity of reference substance was directly placed onto ATR affix or glass slide to undergo consecutive detection.Results For either 5F-AB-PINACA against 5F-AMB or AB-FUBINACA against AMB-FUBINACA,their respective characteristic fragment ions are very similar under both GC-MS and LC-MS/MS,with the relevant fragmentation me chanisms being briefly described.Through FTIR and RS,the infrared absorption peaks and Raman displacement peaks of the two substances from each compared pair are of singleone-cannabinoid-based high specificity an d selectivity with their individual various modified functional groups.Conclusion Simultaneous application of chromatography-mass spectrometry and spectroscopy into identification of novel synthetic cannabinoids is eligible for providing data able to confirm with mutual reference.

关 键 词：法医毒物学 新精神活性物质 合成大麻素 气相色谱质谱 液相色谱串联质谱 傅里叶红外光谱 显微共聚焦拉曼光谱 

分 类 号：DF795.1[医药卫生—法医学]