骨骼组织法医毒物分析研究进展  

Research Progress of Forensic Toxicological Analysis into Skeletal Tissue

作　　者：舒翠霞[1] 华炜婕 董颖[2] 赵璟悠 龚丹 赵嘉祥 SHU Cuixia;HUA Weijie;DONG Ying;ZHAO Jingyou;GONG Dan;ZHAO Jiaxiang(Criminal Investigation Detachment of Suzhou Public Security Bureau,Suzhou 215131,Jiangsu,China;Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China)

机构地区：[1]苏州市公安局物证鉴定所,江苏苏州215131 [2]公安部物证鉴定中心,北京100038

出　　处：《刑事技术》2021年第4期389-393,共5页Forensic Science and Technology

摘　　要：在涉及白骨化、分尸以及尸体高度腐败的案件中,传统的生物检材脏器组织、血液以及其余常规生物样品无法得到,只能提取骨骼组织进行毒物检验,从而获得有价值的信息,但是骨骼组织是一个特殊组织,毒物检验难度大、可利用度低。近年来随着高度灵敏的分析仪器问世,骨骼组织越来越引起毒物检验专家们的兴趣。本文综述了骨骼组织的特点、检测的药毒物、检测样本前处理方法、分析检测方法以及动物实验等有关骨骼组织的研究进展,旨在为有关骨骼组织中毒物的顺利检验及相关研究提供科学参考。At times,cases are suspicious of relating to death from poisoning,yet the traditional toxicological testing is difficult to carry out due to the corpses having decayed into skeletonized remains,fragmented and/or decomposed thoroughly,resulting in unavailability to extract the poisoning chemicals.Accordingly,skeletal tissue is then the only left material for the poisoning substances to extract with such cases although it is not a current welcome sample about doing so.However,skeletal tissue is advantageous in preventing against contamination and decomposition,leaving the potential for toxicological analysis to have the depositing-into-bone toxicants refined with novel and ingenious innovations so that the cold and difficult-to-solve cases could be settled someday.Definitely,the recent publications truly present such endeavors about making the road put through.This paper reviews the comprehensive actuality about toxicological analysis into skeletal tissue.Firstly,the suitable skeletal tissues were commented from the relevant publications,together with their applicable methods including the pretreatment(e.g.,cleaning,drying,crushing and extraction)and instrumental utilization.Secondly,the animal experiments were summarized about the drug distribution and metabolic changes in skeletal tissue under different environmental conditions.Thirdly,targeting to the discrepant drug concentrations between marrow and mineralized bone,the adequate treatments were discussed for separating marrow from mineralized bone so as to independently assess the value of a particular skeletal tissue type in detection of a given drug.Finally,suggestions and prospect were put forward about both the problems waiting for solution and progressive trend,having emphasized the mechanism of drug incorporation into skeletal tissue,which drugs can be detected in skeletal tissue,which type of or certain bone is suitable for toxicological analysis,and the others related.

关 键 词：法医毒物学 骨骼组织 检测技术 动物实验 

分 类 号：DF795.1[医药卫生—法医学]