四草克银方药浴治疗寻常型银屑病血热证的随机对照研究  

A randomized controlled study of Sicaokeyin decoction for the treatment of blood heat syndrome in psoriasis vulgaris

作　　者：郑淇 王玲玲 姜文成 宋勋 王明霞 朱全刚 ZHENG Qi;WANG Lingling;JIANG Wencheng;SONG Xun;WANG Mingxia;ZHU Quangang(Department of Traditioncal Chinese Medicine Dermatology,Shanghai Dermatology Hospital,Shanghai 200443,China;Department of Dermatology,Shanghai Pudong New Area Hospital of Traditional Chinese Medicine,Shanghai 201299,China;Department of Pharmacy,Shanghai Dermatology Hospital,Shanghai 200443,China)

机构地区：[1]上海市皮肤病医院中医皮肤科,上海200443 [2]上海市浦东新区中医医院皮肤科,上海201299 [3]上海市皮肤病医院药剂科,上海200443

出　　处：《世界临床药物》2021年第6期463-467,共5页World Clinical Drug

基　　金：三年行动计划ZY(2018-2020)-ZYBZ-38;上海市科委扬帆计划(21YF1441500)。

摘　　要：目的观察分析中药药浴治疗寻常型银屑病的临床疗效。方法纳入2018年6月至2019年12月于上海市皮肤病医院就诊的144例寻常型银屑病患者为研究对象。根据纳入标准,最终入选141例患者,随机分为两组,试验组(n=71)采用复方青黛胶囊及中药药浴干预,对照组(n=70)采用复方青黛胶囊及麦饭石粉洗浴。观察记录患者皮损、银屑病面积、严重性指数评分(psoriasis area and severity index,PASI)及皮肤病生活质量指数(dermatology life of quality index,DLQI)变化。结果试验组患者愈显率为84.30%,对照组患者愈显率为63.20%,两组差异具有统计学意义(P<0.05);试验组总有效率为94.30%,对照组总有效率为85.30%,两组差异无统计学意义(P>0.05);试验组患者治疗后的PASI评分、DLQI评分明显优于对照组(P<0.05)。结论四草克银方药浴可改善银屑病血热证患者的临床症状。Objective To observe and analyze the clinical effects of traditional Chinese medicine bath in the treatment of psoriasis vulgaris.Methods A total of 144 patients with psoriasis vulgaris who were admitted to Shanghai dermatology hospital from June 2018 to December 2019 were selected as study subjects.According to the inclusion criteria,141 patients were sclected.They were randomly divided into two groups.The experimental group (n=71) was treated with compound Qingdai capsules and herbal medicine bath,while the control group (n=70) was treated with compound Qingdai capsules and wheat rice powder bath.The changes of skin lesions,psoriasis area and severity index (PASI) and dermatology life of quality index (DLQI) were observed and recorded.Results The markedly effective rate of the experimental group was 84.30%,and that of the control group was 63.20%,the difference between the two groups was statistically significant (P<0.05).The total effective rate was 94.30% in the experimental group and 85.30% in the control group,with no statistically significant difference between the two groups(P>0.05).PASI score and DLQI score in the experimental group were significantly better than those in the control group (P<0.05).Conclusion Chinese medicinal bath can significantly improve the clinical symptoms in patients with blood heat syndrome of psoriasis.

关 键 词：四草克银方 药浴 银屑病 血热证 

分 类 号：R275[医药卫生—中医皮科] R751[医药卫生—中医学]