与毛纤维性状相关的角蛋白相关蛋白研究进展  

Research Progress of Keratin-related Proteins Related to Hair Fiber Traits

作　　者：和东迁 陶金忠[1] 陈丽尧 王俊奎 HE Dong-Qian;TAO Jin-Zhong;CHEN Li-Yao;WANG Jun-Kui(School of Agriculture,Ningxia University,Yinchuan 750021,China)

机构地区：[1]宁夏大学农学院,宁夏银川750021

出　　处：《农业生物技术学报》2021年第6期1198-1205,共8页Journal of Agricultural Biotechnology

基　　金：宁夏农业育种专项项目(2013NYYZ0402)。

摘　　要：羊毛纤维是绵羊重要的经济产物之一,羊毛市场的开拓激发人们对羊毛不同性状的需求。角蛋白相关蛋白(keratin-associated proteins,KAPs)基因KRTAPs、角蛋白中间丝(keratin intermediate filaments,KIFs)基因及其各自的变异基因是鉴定羊毛纤维差异遗传基础的候选基因。利用人类或山羊等其他哺乳动物角蛋白的同源基因对绵羊基因组的鉴定,可挖掘新的潜在的功能性KRTAPs或KIFs基因。本文介绍毛囊的形态学结构,回顾角蛋白相关蛋白基因的发展,并对KAP蛋白的在毛囊中的表达与定位进行了描述,最后总结了KRTAPs基因的多态性对羊毛性状的影响。本文为绵羊毛囊生长发育和毛纤维性状的分子选育提供理论依据。Wool fiber is one of the important economic products of sheep.The development of the wool market has stimulated people’s demand for different characteristics of wool.Peratin-associated proteins(KAPs)genes--KRTAPs and keratin-associated proteins(KIFs)genes and their respective variant genes are candidate genes for identifying the genetic basis of wool fiber differences.Using the homologous genes of human or goat and other mammalian keratins,we can identify the sheep genome and explore new potential functional KRTAPs or KIFs genes.In this review,the morphological structure of hair follicles is introduced,and the development of keratin-related protein genes is reviewed.The expression and location of KAP protein in hair follicles are also described.Finally,the effect of KRTAPs gene polymorphism on wool traits is summarized.This review provides a theoretical basis for the molecular breeding of sheep hair follicle growth and development and hair fiber traits.

关 键 词：毛囊 角蛋白 定位 纤维性状 

分 类 号：S826.9[农业科学—畜牧学]