虫草素抗肿瘤药理作用及其机制的研究进展  

Progress on anti-tumor pharmacological effects and mechanism of cordycepin

作　　者：蔡曦 尚超[1] 孟丽荣[2] CAI Xi;SHANG Chao;MENG Lirong(Department of Neurobiology,School of Life Sciences,China Medical University,Shenyang 110022,China;School of Health Sciences and Sports,Macao Polytechnic Institute,Macao 999078,China)

机构地区：[1]中国医科大学生命科学学院神经生物学教研室,辽宁沈阳110122 [2]澳门理工学院健康科学与体育高等学校,澳门999078

出　　处：《药物评价研究》2021年第7期1548-1554,共7页Drug Evaluation Research

基　　金：澳门理工学院资助项目(RP/ESS-04/2017)。

摘　　要：虫草素是冬虫夏草的主要活性成分之一,研究发现其具有抗肿瘤、抗病毒、免疫调节等多种药理活性。近年来,其抗肿瘤作用逐渐成为研究热点,包括肺癌、肝癌、乳腺癌等,其通过腺苷酸活化的蛋白激酶(AMPK)、磷脂酰肌醇-3激酶/蛋白激酶B(PI3K/Akt)、核因子-κB(NF-κB)等多种信号通路来抑制肿瘤细胞增殖、迁移和侵袭,并促进肿瘤细胞凋亡。就虫草素抗肿瘤作用的分子机制、具体应用中的存在问题及对策进行综述,以期为抗肿瘤新药研发提供参考。Cordycepin is one of the main active constituent of the Chinese traditional medicine Cordyceps sinensis.Multiple biological activities of it have been found in past researches,such as anti-tumor,antiviral,and immunomodulation.In recent years,its anti-tumor mechanism has increasingly become a research hotspot,and it has been studied in various tumors such as lung cancer,liver cancer,and breast cancer.It was found that cordycepin inhibits tumor cell proliferation,migration and invasion through AMPK,PI3K/Akt,NF-κB and other signal pathways,and promotes tumor cell apoptosis.The molecular mechanism of cordycepin in different tumors,and the problems in its application and the countermeasures are reviewed,in order to provide a reference for research and development of new anticancer drugs.

关 键 词：虫草素 3'-脱氧腺苷 抗肿瘤 腺苷酸活化的蛋白激酶 磷脂酰肌醇-3激酶/蛋白激酶B 核因子-ΚB 

分 类 号：R285.5[医药卫生—中药学]