氧化苦参碱的血管药理作用研究进展  

Research progress on vascular pharmacologic effect of oxymatrine

作　　者：王承[1] 张明发[2] 沈雅琴[2] WANG Cheng;ZHANG Mingfa;SHEN Yaqin(Department of Pharmacy,Daqing Oilfield General Hospital,Daqing 163001,China;Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)

机构地区：[1]大庆油田总医院药剂科,黑龙江大庆163001 [2]上海美优制药有限公司,上海201204

出　　处：《药物评价研究》2021年第7期1555-1561,共7页Drug Evaluation Research

摘　　要：氧化苦参碱能对抗缺氧、高糖和细菌毒素对血管内皮细胞的损伤,抑制血管内皮-间质转化,也能对抗低氧、转化生长因子-β(TGF-β)、高血脂诱导血管平滑肌细胞增殖以及β-甘油磷酸盐对血管平滑肌细胞的损伤,从而产生血管保护作用和改善血管功能。氧化苦参碱能扩张血管和对抗高糖高脂、苯肾上腺素对血管的挛缩作用;可通过神经节阻断和促进一氧化氮合成和释放,产生降压作用,也能通过改善心功能调节血压;能抑制大鼠因缺氧或野百合碱引起的肺动脉高压和肺血管重构以及高脂饮食引起的动脉粥样硬化。Oxymatrine antagonizes hypoxia, hyper-glucose, and bacteriotoxin-induced vascular endothelial cells injuries, and inhibits vascular endothelial-mesenchymal transition, and antagonizes the proliferation of vascular smooth muscle cells induced by hypoxia,TGF-β and hyperlipemia, and β-glycerophosphate-induced vascular smooth muscle cells injuries, thus produces vascular protection and improves vascular function. Oxymatrine dilates blood vessel and antagonizes vascular contraction induced by hyperglycemia and hyperlipemia, or phenylephrine. Oxymatrine produces hypotension by blocking neuroganglion, and promoting the synthesis and secretion of NO, and regulates blood pressue by improving cardiac function too. Oxymatrine relieves pulmonary hypertension and pulmonary arterial modeling induced by hypoxia or monocrotaline, and hyperliposis diet-induced atherosclerosis in rats.

关 键 词：氧化苦参碱 血管 药理作用 调节血压 动脉粥样硬化 

分 类 号：R285.5[医药卫生—中药学]