盐酸法舒地尔注射液制备工艺研究  

Preparation Process of Fasudil Hydrochloride Injection

作　　者：刘长江 吴双俊 王飞龙 尚艳军 Liu Changjiang;Wu Shuangjun;Wang Feilong;Shang Yanjun(Shandong Fangming Pharmaceutical Group Co.,Ltd.,Dongming 274500,China)

机构地区：[1]山东方明药业集团股份有限公司,山东东明274500

出　　处：《山东化工》2021年第13期26-27,共2页Shandong Chemical Industry

摘　　要：本文对盐酸法舒地尔注射液工艺进行优化,筛选出最佳制备工艺,即氯化钠用量为0.9%,活性炭浓度为0.03%(g/mL),注射液的pH值控制在6.0左右,采用121℃、15 min灭菌方式。盐酸法舒地尔在光照下不稳定,选择棕色玻璃安瓿包装。To optimize the formulation and process of fasudil hydrochloride injection and select the best formulation and process.The optimal prescription was 0.9%sodium chloride,0.03%(g/mL)of the concentration of activated carbon,pH 6 and the optimal sterilization process was 121℃for 15 minutes.Fasudil hydrochloride was unstable under light,and brown glass ampoules were selected.

关 键 词：盐酸法舒地尔注射液 工艺优化 稳定性 

分 类 号：TQ469[化学工程—制药化工] R944.1[医药卫生—药剂学]