水凝胶型伏立康唑微型灌肠剂制备工艺研究  

Preparation Research of Voriconazole Hydrogel Micro-enema

作　　者：于峰 张曼红 田景振 刘建洋 Yu Feng;Zhang Manhong;Tian Jingzhen;Liu Jianyang(Shandong Sheelian Pharmaceutical Co.,Ltd.,Jinan 250000,China)

机构地区：[1]山东绅联药业有限公司,山东济南250000

出　　处：《山东化工》2021年第13期44-45,49,共3页Shandong Chemical Industry

摘　　要：目的:制备水凝胶型伏立康唑微型灌肠剂。方法:选取不同指标,对处方中伏立康唑的溶解以及卡波姆-940、甘油、月桂氮酮等辅料用量进行筛选。结果:采用平均相对分子质量为4500~5500的聚乙二醇单甲醚聚乳酸嵌段共聚物溶解伏立康唑,最佳工艺条件为伏立康唑用量4%,聚乙二醇单甲醚聚乳酸嵌段共聚物用量10%,月桂氮酮用量3%,卡波姆-940用量1%,甘油用量8%,尼泊金乙酯用量0.1%,pH值为6.8。结论:最终确定的处方工艺稳定可行,适合工业化生产。Objective:To prepare voriconazole hydrogel micro-enema.Methods:Choose a method of dissolving voriconazole and select the dosage of carbomer-940,glycerin,azone and other excipients.Results:The results show that Voriconazole was dissolved by polyethylene glycol monomethyl ether polylactic acid block copolymer with an average molecular weight of 4500~5500.4%dosage of voriconazole,10%dosage of polyethylene glycol monomethyl ether polylactic acid block copolymer,3%dosage of azone,1%dosage of carbomer-940,8%dosage of glycerin,0.1%dosage of ethyl Nipagin and pH 6.8 are the best conditions of preparation process.Conclusion:The final prescription technology is stable and feasible,suitable for industrial production.

关 键 词：伏立康唑 微型灌肠剂 制备工艺 

分 类 号：TQ460.6[化学工程—制药化工]