淀粉微球吸附阿司匹林性能的研究进展  

Research Progress of Aspirin Adsorption Properties of Starch Microspheres

作　　者：刘佳 张胜飞 白雪 问娟娟 Liu Jia;Zhang Shengfei;Bai Xue;Wen Juanjuan(School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,Xianyang 712046,China)

机构地区：[1]陕西国际商贸学院医药学院陕西省中药绿色制造技术协同创新中心,陕西咸阳712046

出　　处：《山东化工》2021年第13期65-67,共3页Shandong Chemical Industry

基　　金：2020年大学生省级创新创业训练计划项目“离子液体体系下阿司匹林多孔淀粉微球合成及其对性能研究”(S202013123044);陕西省教育厅专项科研计划项目(20JK0513);陕西国际商贸学院“中药药物研究”创新团队(SSY18TD01)资助项目。

摘　　要：将阿司匹林制成淀粉缓释微球,有效降低药物的毒副作用,提高药物的生物利用率,近年来逐渐成为人们的研究热点。本文主要介绍了阿司匹林淀粉微球及载药方式。并阐述了阿司匹林淀粉微球的性能研究,主要从阿司匹林淀粉微球的评价指标、载药方面及体外释药进行概述。最后并对淀粉微球的发展前景及方向进行了展望。以期为淀粉微球对阿司匹林的载药特性及淀粉微球缓释药物的实际应用提供理论依据。In recent years,it has become a research hotspot that aspirin is made into starch sustained-release microspheres,which can effectively reduce the toxic and side effects of drugs and improve the bioavailability of drugs.This paper mainly introduces aspirin starch microspheres and drug loading methods.The performance research of aspirin starch microspheres was described,including the evaluation index,drug loading and drug release in vitro.Finally,the development prospect and direction of starch microspheres were prospected.In order to provide a theoretical basis for the drug loading characteristics of starch microspheres for aspirin and the practical application of starch microspheres sustained-release drugs.

关 键 词：淀粉微球 阿司匹林 载药方式 性能研究 

分 类 号：TQ460.4[化学工程—制药化工]