抗中性粒细胞胞浆抗体相关性肾小球肾炎生物标志物研究进展  

Biomarkers of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis

作　　者：瞿转 王惠明[1] QU Zhuan;WANG Hui-ming(Department of Nephrology,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China)

机构地区：[1]武汉大学人民医院肾内科,湖北武汉430060

出　　处：《中华实用诊断与治疗杂志》2021年第7期739-742,共4页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(81370800);湖北省技术创新专项(2019ACA137)。

摘　　要：抗中性粒细胞胞浆抗体(anti-neutrophil cytoplasmic antibody, ANCA)相关性血管炎是一组以小血管壁炎症和纤维素样坏死为病理特征的自身免疫性疾病,累及肾脏时称为ANCA相关性肾小球肾炎(ANCA associated glomerulonephritis, AAGN)。应用糖皮质激素联合免疫抑制剂治疗后70%-90%的AAGN患者症状可缓解,但缓解后易复发,20.8%-39.5%的患者至少复发1次,复发的机制目前尚不清晰。寻找诊断AAGN、评估AAGN疾病活动度的指标是临床关注的热点。本文就AAGN相关生物标志物的研究进展作一综述。Anti-neutrophil cytoplasmic antibody-associated vasculitis is a group of autoimmune systemic diseases characterized by inflammation and fibrinoid necrosis of small blood vessel walls,and it is named ANCA-associated glomerulonephritis(AAGN)when involving the kidneys.Glucocorticoid combined with immunosuppressant can relieve the symptoms in 70%to 90%of AAGN patients,but 20.8%to 39.5%of patients have at least one relapse afterwards.The mechanism of relapse has not been defined.To explore the markers of AAGN diagnosis and AAGN activity assessment has been the clinical focus.This paper reviews the research progress of AAGN-associated biomarkers.

关 键 词：抗中性粒细胞胞浆抗体相关性肾小球肾炎 抗中性粒细胞胞浆抗体相关性血管炎 生物标志物 免疫抑制剂 

分 类 号：R692.31[医药卫生—泌尿科学]