支气管哮喘患儿血清sICAM-1、MMP-9水平与气道炎症、重塑的关系探讨  

The Relationship of Serum sICAM-1 and MMP-9 Levels with AirwayInflammation and Remodeling in Children with Bronchial Asthma

作　　者：杨晓兰[1] 张洪 杨训永[1] 李群[1] YANG Xiaolan;ZHANG Hong;YANG Xunyong;LI Qun(The Third People’s Hospital of Chengdu,Chengdu 610000,China)

机构地区：[1]成都市第三人民医院,四川成都610000

出　　处：《标记免疫分析与临床》2021年第7期1146-1150,共5页Labeled Immunoassays and Clinical Medicine

基　　金：四川省卫生厅科研项目(编号:19PJ1501)。

摘　　要：目的探讨支气管哮喘患儿血清可溶性细胞间黏附分子-1(sICAM-1)、基质金属蛋白酶-9(MMP-9)水平与气道炎症、重塑的关系。方法选取2018年2月至2020年9月于本院接受治疗的支气管哮喘患儿62例作为观察组,同期体检健康的40例儿童作为对照组,收集两组血常规资料及外周血2 mL,检测血清sICAM-1、MMP-9水平,采用高分辨率CT扫描肺部并计算气道壁厚度/气道管腔外径(T/D)、气道壁面积占气道总截面积百分比(WA%),分析sICAM-1、MMP-9水平与气道炎症指标、气道重塑的相关性。结果观察组sICAM-1、MMP-9、嗜酸性粒细胞计数、T/D、WA%显著高于对照组(P<0.01);重度组患儿血清sICAM-1、MMP-9、嗜酸性粒细胞计数、T/D、WA%水平显著高于轻、中度组(P<0.01);哮喘患儿血清sICAM-1与嗜酸性粒细胞计数、T/D、WA%呈线性正相关(r=0.325、0.248、0.356,P<0.01),MMP-9水平与嗜酸性粒细胞计数、T/D、WA%呈线性正相关(r=0.489、0.437、0.572,P<0.01)。治疗后,观察组血清sICAM-1、MMP-9显著降低(P<0.01)。结论支气管哮喘患儿血清sICAM-1、MMP-9高于正常水平,与气道炎症及重塑指标具有相关性,可能在炎症进展及气道重塑进程中起到重要作用。Objective To investigate the relationship of serum soluble intercellular adhesion molecule-1(sICAM-1)and matrix metalloproteinase-9(MMP-9)levels with airway inflammation and remodeling in children with bronchial asthma.Methods Atotal of 62 patients with bronchial asthma(observation group)and 40 healthy children(control group)were enrolled in this study between February,2018 and September,2020.The blood routine data and 2 mL of peripheral blood were collected from the two groups to test serum sICAM-1 and MMP-9 levels.High-resolution CT scan was conducted to scan lungs and calculate the airway wall thickness/outer diameter of the airway lumen(T/D)ratio,and the percentage of airway wall area in total airway cross-sectional area(WA%).The correlation of sICAM-1 and MMP-9 levels with airway inflammation indicators and airway remodeling was analyzed.Results The sICAM-1,MMP-9,eosinophil count,T/D,and WA%in the observation group were significantly higher than those in the control group(P<0.01).Serum sICAM-1 and MMP-9 levels,eosinophil count,T/D and WA%in the severe group were significantly higher than those in the mild group and moderate group(P<0.01).There was a linear positive correlation between serum sICAM-1 level and eosinophil count,T/D and WA%in children with asthma(r=0.325,0.248,0.356,P<0.01),and the same for MMP-9 level(r=0.489,0.437,0.572,P<0.01).After treatment,serum sICAM-1 and MMP-9 levels in the observation group were significantly reduced(P<0.01).Conclusion Serum sICAM-1 and MMP-9 levels are elevated in children with bronchial asthma,which are correlated with airway inflammation and remodeling indicators,suggesting that these markers may play an important role in the progression of inflammation and airway remodeling.

关 键 词：支气管哮喘 可溶性细胞间黏附分子-1 基质金属蛋白酶-9 炎症 气道重塑 

分 类 号：R562.25[医药卫生—呼吸系统]