Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager  

作　　者：Filiz Yesilkoy Roland A Terborg Josselin Pello Alexander A Belushkin Yasaman Jahani Valerio Pruneri Hatice Altug 

机构地区：[1]Institute of BioEngineering,École Polytechnique Fédérale de Lausanne,CH-1015 Lausanne,Switzerland [2]ICFO-Institut de Ciències Fotòniques,The Barcelona Institute of Science and Technology,08860 Castelldefels(Barcelona),Spain [3]ICREA-InstitucióCatalana de Recerca i Estudis Avançats,08010 Barcelona,Spain

出　　处：《Light(Science & Applications)》2017年第1期159-167,共9页光（科学与应用)（英文版）

基　　金：funded by the European Union’s Horizon 2020 research and innovation program under Grant Agreement No.644956(RAIS project);the North Atlantic Treaty Organization’s Public Diplomacy Division in the framework of‘Science for Peace’(NATO—SPS),École Polytechnique Fédérale de Lausanne research fund,FundacióPrivada Cellex;the CERCA Programme/Generalitat de Catalunya;support from the International PhD fellowship program‘la Caixa’—Severo Ochoa@ICFO;support from the International PhD fellowship program'la Caixa'-Severo Ochoa@ICFO;support from the Spanish Ministry of Economy and Competitiveness,through the‘Severo Ochoa’Programme for Centres of Excellence in R&D(SEV-2015-0522);project OPTO-SCREEN(TEC2016-75080-R).

摘　　要：Nanophotonics,and more specifically plasmonics,provides a rich toolbox for biomolecular sensing,since the engineered metasurfaces can enhance light–matter interactions to unprecedented levels.So far,biosensing associated with high-quality factor plasmonic resonances has almost exclusively relied on detection of spectral shifts and their associated intensity changes.However,the phase response of the plasmonic resonances have rarely been exploited,mainly because this requires a more sophisticated optical arrangement.Here we present a new phase-sensitive platform for high-throughput and label-free biosensing enhanced by plasmonics.It employs specifically designed Au nanohole arrays and a large field-of-view interferometric lens-free imaging reader operating in a collinear optical path configuration.This unique combination allows the detection of atomically thin(angstrom-level)topographical features over large areas,enabling simultaneous reading of thousands of microarray elements.As the plasmonic chips are fabricated using scalable techniques and the imaging reader is built with low-cost off-the-shelf consumer electronic and optical components,the proposed platform is ideal for point-of-care ultrasensitive biomarker detection from small sample volumes.Our research opens new horizons for on-site disease diagnostics and remote health monitoring.

关 键 词：interferometric imaging label-free plasmonic biosensors lens-free imaging phase interrogation point-of-care devices protein microarray detection 

分 类 号：TB3[一般工业技术—材料科学与工程]