Off-axis holography and micro-optics improve lab-on-a-chip imaging  

作　　者：Zachary S Ballard Yibo Zhang Aydogan Ozcan 

机构地区：[1]Department of Electrical Engineering and Bioengineering,California NanoSystems Institute,University of California,Los Angeles,CA 90095,USA

出　　处：《Light(Science & Applications)》2017年第1期226-227,共2页光（科学与应用)（英文版）

摘　　要：A pocket holographic slide enables the high-throughput screening of fluid samples by embedding micro-optics directly on a microchannel to achieve off-axis interferometric imaging.This holographic slide can be used to turn a conventional microscope into a phase-contrast imager or as a stand-alone compact imaging device by incorporating polymer lenses that are printed directly on-chip.For decades,researchers have been developing lab-on-a-chip(LoC)technologies integrated with optics in an attempt to bring sensitive diagnostic measurements to practical and fully contained systems,which can be used at the point-of-care and in resource-limited settings1.Digital holography(DH)is an imaging technique that is particularly well suited for LoC technologies because(i)it is label-free,which means that it does not require any sample pretreatment or labeling steps,thus forgoing the need for costly reagents and their refrigeration,and(ii)it can be easily incorporated with fluids to quickly screen large volumes of biofluids such as blood,serum,urine and saliva.

关 键 词：OPTICS HOLOGRAPHIC STEPS 

分 类 号：O43[机械工程—光学工程]