Multispectral sensing of biological liquids with hollow-core microstructured optical fibres  

作　　者：Timur Ermatov Roman E.Noskov Andrey AMachnev Ivan Gnusov Vsevolod Atkin Ekaterina N.Lazareva Sergei V.German Sergey S.Kosolobov Timofei S.Zatsepin Olga V.Sergeeva Julia S.Skibina Pavel Ginzburg Valery V.Tuchin Pavlos G.Lagoudakis Dmitry A.Gorin 

机构地区：[1]Skolkovo Institute of Science and Technology,3 Nobelya str.,Moscow 121205,Russia [2]Department of Electrical Engineering,Tel Aviv University,Ramat Aviv,Tel Aviv 69978,Israel [3]Light-Matter Interaction Centre,Tel Aviv University,Ramat Aviv,Tel Aviv 69978,Israel [4]Saratov State University,83 Astrakhanskaya str.,Saratov 410012,Russia [5]Tomsk State University,36 Lenin’s av.,Tomsk 634050,Russia [6]M.V.Lomonosov Moscow State University,Leninskie Gory,1-3,Moscow 119992,Russia [7]SPE LLC Nanostructured Glass Technology,10150 Let Oktjabrja,Saratov 410033,Russia [8]Center for Photonics and 2D Materials,Moscow Institute of Physics and Technology,Dolgoprudny 141700,Russia [9]Institute of Precision Mechanics and Control of the Russian Academy of Sciences,24 Rabochaya str.,Saratov 410028,Russia

出　　处：《Light(Science & Applications)》2020年第1期346-357,共12页光（科学与应用)（英文版）

基　　金：supported by the Russian Foundation for Basic Research(RFBR grant no.19-32-90249);supported by RFBR grant no.18-52-16025;supported by RFBR grant no.18-29-08046;supported in part by the Ministry of Science&Technology of Israel(grant no.79518).

摘　　要：The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance.This common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral domain.Here,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOS).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells.IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral ranges.We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

关 键 词：refractive SPECTRAL microstructure 

分 类 号：TN253[电子电信—物理电子学]