用SI-ATRP方法改善高分子材料血液相容性的常用生物活性单体  

Commonly Used Bioactive Monomers for Improving Blood Compatibility of Polymer Materials by SI-ATRP

作　　者：张畅[1] ZHANG Chang(Patent Examination Cooperation Guangdong Center of the Patent Off ice,Guangzhou 510000,China)

机构地区：[1]国家知识产权局专利局专利审查协作广东中心,广东广州510000

出　　处：《化工管理》2021年第22期162-163,共2页Chemical Engineering Management

摘　　要：血液相容性主要是研究材料与血液直接接触后是否引发血小板聚集、凝血及血栓形成和溶血现象等问题。通常从抗凝血性能和保持血液成分完整性两方面对材料的血液相容性进行评价。文章研究了用表面引发-原子转移自由基聚合(SI-ATRP)方法改善高分子材料血液相容性的常用生物活性单体—聚乙二醇类、磷酰胆碱类、内盐类、肝素类等的特点和相关研究进展。Biocompatibility or blood compatibility is mainly to study the problems of platelet aggregation,coagulation,thrombosis and hemolysis caused by direct contact between materials and blood.The blood compatibility of materials is usually evaluated from two aspects:anticoagulant performance and maintaining the integrity of blood components.This paper studies the commonly used bioactive monomers used in surface-initiated-atom transfer radical polymerization(SI-ATRP)to improve the blood compatibility of polymer materials-polyethylene glycols,phosphorylcholines,internal salts,the characteristics of heparins and related research progress.

关 键 词：生物相容性 SI-ATRP 高分子 凝血 血栓 

分 类 号：R11[医药卫生—公共卫生与预防医学]