补骨脂的化学成分研究  

Chemical Constituents of Psoralea corylifolia L.

作　　者：高胡彤悦 高盼盼 臧应达 马洁[1] 杨敬芝[1] 叶菲[1] 李创军[1] 张东明[1] GAO Hutongyue;GAO Panpan;ZANG Yingda;MA Jie;YANG Jingzhi;YE Fei;LI Chuangjun;ZHANG Dongming(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所,天然药物生物活性物质和功能国家重点实验室,北京100050

出　　处：《中国药物警戒》2021年第6期556-561,共6页Chinese Journal of Pharmacovigilance

基　　金：国家重点研发计划(2019YFC1711000);国家自然科学基金资助项目(21772234);中国医学科学院医学与健康科技创新工程(2016-I2M-2-003,2019-I2M-1-005)。

摘　　要：目的研究补骨脂(Psoralea corylifolia L.)的化学成分。方法利用硅胶柱色谱,MCI柱色谱,ODS柱色谱以及高效液相色谱等分离手段,对补骨脂的95%乙醇提取物进行化学成分研究,并通过质谱和核磁共振等波谱数据对分离得到的化合物进行结构鉴定。结果从补骨脂的95%乙醇提取物中分离鉴定10个化合物,分别是seputhecarpan A(1)、补骨脂酚(2)、13-羟基异补骨脂酚(3)、12-羟基异补骨脂酚(4)、二聚补骨脂酚A(5)、二聚补骨脂酚B(6)、二聚补骨脂酚C(7)、4,2′-二羟基-4′-甲氧基-5′-(3′′,3′′-二甲基烯丙基)-查尔酮(8)、isobavachromene(9)、4-hydroxyisolonchocarpin(10)。结论化合物1首次从该植物中分离得到。蛋白质酪氨酸磷酸酶1B(PTP1B)抑制活性实验,结果显示化合物2和7具有PTP1B抑制活性。Objective To analyze the chemical constituents of the fruit of Psoralea corylifolia L..Methods 95%ethanol extract of Psoralea corylifolia L.was studied with silica gel,MCI,ODS column chromatography and high performance liquid chromatography.The structure was elucidated with MS and NMR.Results Ten compounds were isolated from 95%ethanol extract of Psoralea corylifolia L..They were seputhecarpan A(1),bakuchiol(2),13-hydroxyisobakuchiol(3),12-hydroxyisobakuchiol(4),bisbakuchiol A(5),bisbakuchiol B(6),bisbakuchiol C(7),4,2'-dihydroxy-4'-methoxy-5′-(3'',3''-dimethylallyl)-chalkone(8),isobavachromene(9)and 4-hydroxyisolonchocarpin(10).Conclusion Compound 1 was isolated from this plant for the first time.The results of evaluation of PTP1B inhibitory activities showed that compounds 2 and 7 displayed significant PTP1B inhibitory activities.

关 键 词：补骨脂 单萜酚 黄酮 PTP1B抑制活性 

分 类 号：R961[医药卫生—药理学]